血脂分析测试的国家指南

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1、NationalGuidelinesonLipidProfileTestingE-mail:yanshengkai@sina.comDr.Sheng-kaiYan,PhDDepartmentofLaboratoryMedicine,PekingUnionMedicalCollegeHospitalProfessorzhouxinDepartmentofLaboratoryMedicine,Zhongnanhospitalofwuhanuniversity.PrefaceBloodlipidanalysishasasubst

2、antialimportancetowardsthepreventionandmanagementofatherosclerosisandcoronaryheartdisease(CHD).Itisalsobeingwidelyappliedtothestudiesofmanyotherrelatedclinicalconditions,suchasdiabetesmellitus,kidneydiseases,andmetabolicdisordersinpostmenopausalwomen.Recently,theL

3、ipidExpertPaneloftheChineseSocietyofLaboratoryMedicine(CSLM)oftheChineseMedicalAssociation(CMA)hascomeupwiththepracticalguidelinesandrecommendationsonlipidprofiletesting.lipidprofiletesting:totalcholesterol(TC)triglycerides(TG)highdensitylipoprotein–cholesterol(HD

4、L-C)lowdensitylipoprotein-cholesterol(LDL-C)apolipoproteinA1(ApoA1)apolipoproteinB(ApoB)lipoprotein(a)[Lp(a)]TheGuidelinesincludethecontentasfollows,PrefacePreanalyticalfactorsaffectinglipidtestresultsMethodsoflipidanalysisReagentselectioncriteriaandpracticalguide

5、linesClinicalsignificanceofcutoffvaluesintheinterpretationoflipidprofileresultsSee:ChinJLabMed,2003,26(3):182~184中华检验医学杂志,2003,26(3):182-184PreanalyticalFactorsAffectingLipidTestResultsAsubject’slipidprofileshouldbemeasuredwhentheindividualisinasteadymetabolicstat

6、e.Subjectsshouldmaintaintheirusualdietandweightforatleast2weekspriortothemeasurementoftheirlipidsorlipoproteins.Subjectsshouldnotperformvigorousphysicalactivityduringthe24hourspriortotesting.RecommendationsforminimizingpreanalyticalvariationMultiplemeasurementssho

7、uldbeperformedwhthin2months,atleastoneweekapart,beforemakingamedicaldecisionaboutfurtheraction.Fastingornon-fastingspecimenscanbeusedforTCtesting.However,a12-hfastingspecimenisrequiredforTGandrecommendedforlipoproteins.Thesubjectshouldbeseatedforatleast5minutesbef

8、orespecimencollection.Thetourniquetshouldnotbekeptonmorethanoneminuteduringvenipuncture.Suggestionstoreducethepreanalyticalvariationsonbloodlipidprofile