皮肤性病学精品教学(汕头大学)psoriasis银屑病课件

皮肤性病学精品教学(汕头大学)psoriasis银屑病课件

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时间:2018-10-02

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1、PSORIASISWhatisPsoriasis?Psoriasisisachronic,inflammatorydermatosischaracterizedbywell-demarcatederythematousplaquestoppedbysilveryscales.Howdoespsoriasisoccur?inheritanceenvironmentimmunityinheritance16%50%environmentinfectionendocrinetensionstressother:drug、smoke、drinkinfectionTypically,

2、astreptococcalsorethroatmayprecipitateguttatepaoriasisendocrinepregnancydeliverytensiontensionwoundincitementbloodvessel、motornervepsoriasisaggravateinducedstresstraumasurgeryotherDrugBeta-blockers,lithiumandantimalarialscanmakepsoriasisworseorprecipitateit.Cigarettesandalcoholseemtomakeps

3、oriasisworse.immunityfactorimmunologydisorderT-LymphocytesCytokinesKeratinocytesClinicalManifestationpsoriasisvulgarispsoriasispustulosapsoriasisarthropathicapsoriasiserythrodermicpsoriasisvulgarisknee、elbow、sacrumwell-definedredplaquesilver-whitescalepsoriasisvulgarispsoriasisvulgarispsor

4、iasisvulgarisMembranephenomenonpsoriasisvulgarisAuspitzsignpsoriasisvulgarisscalpmucosalnailguttatescalpBunchinesshairMucosalglansforeskinoralcavityNailPsoriasisaffectsthenailin25-50%ofcases.ThimblepittingOnycholysisthickenToenailsThimblepittingthickenOnycholysisToenailsGuttateAdolescentso

5、ryoungadultsStreptococcalthroatinfectionAcutesymmetricaleruptionof“drop-like”lesionswithlittlescaleintheearlystageUsuallyonthetrunkandlimbs0.3~0.5cmpsoriasisvulgarissometimesitchCourseAdvanceStillRecessionAdvanceKoebnerphenomenon.StillNonewrashRecessionRashgraduallyreducedpsoriasisarthropa

6、thicapsoriasisarthropathicapsoriasisarthropathicapsoriasispustulosawithdrawalofsteroidsorimmunodepressant,orpotentstimulationdrugGeneralizedandlocalizedformsGeneralizedpustularacutesheets,small,sterileyellowishpustulesdeveloponanerythematousbackgroundfeverPalmoplantarpustulosisLocalizedont

7、hepalmsorsoles,symmetryCharacterizedbyyellowtobrown-colouredsterilepustulesNailerythrodermicpsoriasiswithdrawalofsteroids,oranintercurrentdrugeruptionthespecificfeaturesofpsoriasisareloseHistopathologyHistopathologyhyperkeratosisparakeratosisgranularlayeracant

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