中药雾化透皮法治疗痹病的临床研究.doc

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1、中药雾化透皮法治疗痹病的临床研究【摘要】目的研究中药汽疗仪辨证用药雾化透皮外治寒湿阻络证、寒热错杂证、痰瘀阻络证为主的风湿、类风湿、强直性脊柱炎、颈肩腰腿痛的临床疗效及安全性。方法将376例风湿、类风湿、强直性脊柱炎、颈肩腰腿痛患者随机按3∶1比例设立对照；治疗276例依据临床证型分别选用痹复康Ⅰ、Ⅱ、Ⅲ号浴剂；对照组100例用食醋、羌活、威灵仙，疗程均为20天，对临床疗效、观察指标、实验室指标进行综合评估。结果治疗组对风湿、类风湿、强直性脊柱炎、颈肩腰腿痛、寒湿阻络证、寒热错杂证、痰瘀阻络证总有效率分别为98.89%，94.00%，96.15%，94.0

2、5%，98.22%，94.84%，95.52%；对照组分别为46.67%，20.00%，13.33%，45.00%，41.46%，10.53%，47.62%，显示中药汽疗仪辨证施药雾化透皮法对四病三证的总有效率均超过90%，对照组总有效率均未能达到50%，两组病证分别相比较，差异有统计学意义（P＜0.01或P＜0.001）；治疗组在改善临床症状、体征和实验室指标等方面的疗效肯定（P＜0.05或P＜0.01），研究过程中未发现严重的不良反应。结论中药汽疗仪辨病辩证用药雾化透皮法是治疗以寒湿阻络证、寒热错杂证、痰瘀阻络证为主的风湿、类风湿、强直性脊柱炎、颈肩腰

3、腿痛等病证有肯定疗效的一种新方法且较安全。【关键词】痹证/中药疗法；皮肤吸收；中药离子透入［Abstract］ObjectiveToresearchthetherapeuticeffectandsafetyofnebulizertransdermaldrugbyvapourtherapyindialecticaltreatingonberiberoiddisease，rheumatoid，ankylosingspondylitic，painsonneck-shoulder-waist-leg，whichwerecausedbyretentionofcold

4、-dampinthecollaterals，cold-heatcomplicatedsyndrome，obstructionofcollateralscoldhygrosis.MethodsThreehundredandseventy-sixcaseswererandomlydividedintotwogroups.Twohundredandseventy-sixcasesweretreatedwithBifukangBalneumⅠ，Ⅱ，Ⅲasthestudygroup，while100casesweretreatedwithvinegarandChin

5、eseclematisrootasthecontrolgroup，withatreatmentcourseof20daysforbothgroups.Therapeuticeffect，observationindexandlaboratoryindexwerecompositivelyevaluated.ResultsThetotaleffectiveratesforberiberoiddisease，rheumatoid，ankylosingspondyliticdialectical，painsonneck-shoulder-waist-leg，re

6、tentionofcold-dampinthecollaterals，cold-heatcomplicatedsyndrome，obstructionofcollateralscoldhygrosisinthestudygroupwere98.89%，94.00%，96.15%，94.05%，98.22%，94.84%，95.52%，whilethecontrolgroupwere46.67%，20.00%，13.33%，45.00%，41.46%，10.53%，47.62%.Thetotaleffectiverateofthestudygroupwasm

7、orethan90%whilethatofthecontrolgroupwaslessthan50%.Therewasgreatdifferenceintwogroups（P＜0.01orP＜0.001）.Thetherapeuticeffectofthestudygrouponimprovingclinicalsymptom，physicalsignandlaboratoryindexisconfirmed（P＜0.05orP＜0.01）andwithoutobvioussideeffect.ConclusionThenebulisertransderm

8、aldrugbyvapour5therapymeterindial