病毒性肝炎实验室诊断

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1、LaboratorydiagnosisofViralHepatitis谭龙益HistoryofHumanHepatitis500B.C.writtenaccountsofjaundiceinBabylonia400B.C.Hippocratesdescribes“epidemicjaundice”1883jaundicenotedtooccurafterinoculationofhumansera1941post-vaccinationjaundiceoccursin>28,000U.S.soldiersinfectioushepatitisdesignatedHep

2、atitisA;serumhepatitisdesignatedHepatitisB1962HepatitisBSurfaceAntigenidentified1973HepatitisAidentifiedbyelectronmicroscopyMid-1970’sHepatitisDrecognizedMid-1970’sNon-A,Non-BhepatitisdescribedMid-1980’sepidemicsof“non-hepatitisA”enterichepatitis1989HepatitisCclonedandserologicaltestsde

3、veloped1990HepatitisEclonedandcharacterizedHFVor1995HGV1997TTVSEN-V2006NF-VOtherVirusesCausingHepatitisHepatitisGandGBTTViruspost-transfusionalhepatitisinJapanSanban,Yonban,TLMVGiantCellHepatitisparamyxovirus;HerpesVirusesHSVCytomegalovirusEpsteinBarrVirusRiftValleyFeverVirusYellowFever

4、VirusLassaVirusMarburgVirusEbolaVirusAdenoviuresEnteorvirusesCoxsackieVirusesSARS肝炎病毒的定义及种类ViralhepatitishepatitisVirusHepatitisAvirusHAVHBVHCVHDVHEVHepatitisFvirusHFVHGVTTVSENNV-FHepatitisFVirusHepatitisFVirus血清血清急性肝炎急性肝炎急性肝炎GBagentHGV1966年DeinhardtG.Barker两株RNA病毒GBvirustypeAGBV/AGBvir

5、ustypeBGBV/B肝炎病人GBvirustypeCGBV-C1995年急、慢性非甲~戊型肝炎病人hepatitisGvirusHGVHepatitisGvirus(HGV)Science.1996Jan26;271(5248):505-8.AnRNAvirusentiregenome(9392nucleotides)encodingapolyproteinof2873aminoacids.fromtheplasmaofapatientwithchronichepatitis.GBV-C感染的流行病学GBV-C感染与人类疾病的关系前瞻性和回顾性研究单独感染：不引起

6、急、慢性肝炎之间的联系与其它肝炎病毒共感染：不影响肝炎的发生和发展过程长期携带GBV-C病毒：不增加肝癌等疾病发生风险不增加其它临床疾病的发生和发展主要在外周血淋巴细胞中复制。GBV-C与HIV共感染对HIV感染者的影响《C型GB病毒/庚型肝炎病毒对HIVLTR启动子活性的调控作用研究》E2envelopeproteinofGBV-C/HGVJPhysChemB.2009May21;113(20):7383-91SyntheticpeptidesofhepatitisGvirus(GBV-C/HGV)intheselectionofputativepeptideinh

7、ibitorsoftheHIV-1fusionpeptide.HerreraE,GomaraMJ,MazziniS,RaggE,HaroI.Torquetenoviruses(TTV)transfusion-transmittedvirus(TTV)3.8kbDNAvirus，6genotypes.transmit：parenteralroutes.globally，healthy，variousdiseasegroups.livertropismliverdiseases.multipliesinbonemarrowcellsandPBMCsTTv