高血压英文ppt精品课件global salt initiatives from evidence to worldwide

《高血压英文ppt精品课件global salt initiatives from evidence to worldwide 》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、GlobalSaltInitiativesFromEvidencetoWorldwideImplementationGrahamAMacGregorworldactiononsalt.comEzzatietal.Lancet2002:360:1347-60.UnderweightUnsafesexHighcholesterolTobaccoRaisedBloodPressure01234567MillionsofDeaths7millionDevelopingregionDevelopedregionRaisedBPisresponsiblefor62%ofallStrokes&49%ofal

2、lHeartDiseaseMajorUnderlyingFactorsCausingDeath-WorldwideSystolicBloodPressure(mmHg)HeartDeaths168421120125135148168Risk1201251351481682481632StrokeDeathsTheriskstartsatsystolic115mmHg(83%adults)RiskMacMahonetal.Lancet1990;335:765-74SystolicBPandRiskofDeathPlaqueUlceratedPlaqueFissuredPlaquewithThro

3、mbosisAtheromaincarotidarteryWhatputsuppopulationBP?SaltintakeLackoffruitandvegetablesWeightLackofexercise(Alcoholexcess)He&MacGregor.JHH2008on-linefirst.doi:10.1038/jhh.2008.144.Upto5000yrsago0.1g/d,now10to12g/dWhy?PreservesfoodCleansupbadfoodRefrigerationBetterchemicalsNownoneedButeating10to12g/d-

4、courtesyofthefoodindustry80%ofsalthiddeninfood(a)(b)ProcessedFastRestaurantCanteenSalt,diet&health.1998,CambUniPressSaltEvidenceEpidemiologyOver50populationstudiesandIntersaltMigratione.g.KenyaInterventionPortuguesevillages.NewbornbabiesGeneticAlldefectsimpairabilityofthekidneytoexcreteNaMechanismsP

5、lasmaNa,correctedvolumeexpansionAnimalBPcausedoraggravatedbysalt(e.g.chimpanzees)TreatmentTrials,Meta-analysis.DoseresponseMortalitystudiesFinland(24hUNa)OutcometrialsTOHP,Taiwan(mineralsalt:highK,lowNa)He&MacGregor.JHH2008on-linefirst.doi:10.1038/jhh.2008.144.HypertensiveNormotensiveFallinSystolicB

6、P(mmHg)UsualsaltintakeReducedsaltintakeUrinarySodium(mmol/24h)P<0.001reducedsaltvs.usualsaltintake.Meta-analysisofModestSaltReductionTrialsofonemonthorLongerHe&MacGregor.JHH2002;16:761-770-20-4-6100501500Stroke24%CHD18%He&MacGregor.Hypertension2003;42:1093-99saltintake6g/dayUSA150,000(approx)deat

7、hsprevented/yearWorldwide2.5million(approx)Stroke&Heartattackdeathsprevented/yearAvg.5mmHgSaltintake(10–12g/day)ReducesaltintakePopulationBP,riseinBPwithage,hypertensionOthereffectse.g.stomachcancer,