透明质酸在骨关节疾病中的应用

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1、中国组织工程研究jl}{ii床康复彩74誉第472010—11—19m版JournalofClinicalRehabilitativeTissueEngineeringResearchNovember19，2010VO／．14．No．47透明质酸在骨关节疾病中的应用☆伞棋．j,if新，裴兴，伞箭ApplicationofhyaluronicacidsforosteoarthriticdiseaseLiQi，TangXin，PeiFu—xing，LiJianAbstractDepartmentofBACKGROUND：Hyaluronicacid．apolymerpolys

2、accharide．hasacertainefectoncheosteoarthriticdiseasesandhasbeenOrthopaedicSurge~widelyused．Butjtsmechanismisnotentirelyclearandthespecificefectremainsdisputes．SohowtoselectappropriateWestChinaHospitai．patients．appropriatedrugsforgeeinggreatereficacyandreducingsideefectshasbecometheaimsofm

3、anyscholars．SichuanUniversity．Chengdu610041OBJECTIVE：Toreviewtheapplication．underlyingmechanism．safety，eficacy．indicationsandadversereactionsofhyaluronicSichuanProvince，acidusedforOsleOarthriticdiseases．ChinaMETHODS：Acomputer-basedonlinesearchofCNKI(wwW．cnki．net)andPubMeddatabase(www．pubm

4、ed．com)wasLiO-☆．Studyingforperformedwithkeywordsof“hyaluronicacid．fractures．arthritis”inChineseand“hyaluronicacid．hyaluronan．osteoarthritisdoctorate，Atendingfracture”inEnglishphysician，RESULTSANDCONCLUSION：Finaly．47literatureswereincludedforanalysis．HyaluronicacidissafeandefectiveforDepar

5、tmentofOrthopaedicSu哼ery．osteoarthriticdiseases．Themainmechanismsare：coverage．1ubrication，cushioningcartilagestress；reducingtheintra—articularWestChinaHospibI．inflammation；promotingthesecretionofendogenoushyaluronicacid．StrictcontroIofitsIndicationsandselectionofsuitableSichuanUniversity,

6、molecularweighthyaluronicacidcanincreasethesymptomaticreliefandimprovetreatmentsatisfaction，whilereducingtheChengdu61OO41SichuanProvince，medicaIdatawasterandadverseeventsButsomeproblemssuchasIhecourseofhyaluronicacidtreatment．intervaIanddrugChinaselectionarestilIdisputableandrequirefurthe

7、rstudy．liqimm@163comCorrespondenceto：LiQ．TangX．PeiFX．LIJ．Applicationofhyaluronicacidsforosteoarthriticdisease．ZhongguoZuzhiGongchengYanjiuyuLiJian，Professor,LinchuangKangfu．2010：14(47)：8835—8839．【http：／／www．crter．cnhttp：／／en．zglckfcom】DepartmentofOrthopaedicSu~ew．We