正文描述:《浅析糖尿病性癫痫》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、Analysisofdiabeticepilepsy(浅析糖尿病性癫痫)Diabeticacuteonset,severesymptoms,oftentheinitialdiagnosisinneurology,emergencydepartment,intheabsenceofclearhistoryofdiabetescases,wasnoteasytodiagnosis.Andinrecentyearsofdiabeticepilepsyandepilepticstatusinclinicalreportsofincreasing,atpresentthatisalsoone
2、oftheneurologicalcomplicationsofdiabetes.OnsomewithoutaclearhistoryofdiabetespatientsareoftenfirstvisitstotheDepartmentofneurology.糖尿病性发病急、症状重,常首诊于神经科、急诊科,在无明确的糖尿病史情况下,不易被诊断。且近年来糖尿病性癫痫及癫痫状态的临床报告日见增多,目前认为亦是糖尿病神经系统并发症之一。对一些无明确糖尿病史的患者常常首先就诊于神经科。 Diabeticseizureoccurrencemechanismhasnotbeenfullye
3、lucidated,combinedwithsummarizingtherelatedinformationbelow: 糖尿病性癫痫的发生机制至今尚未完全阐明,结合患者总结其相关资料如下: (1)thedisease,elderly,(inparticular,mainlytheelderly,accompaniedbyfundamentaldiseasediabetesordiabetesmellitus,patientshavedifferentdegreeofcerebralatherosclerosisandimpairedbrainfunction,localcer
4、ebralbloodflowregulationfunctiondeclines,maybecomeseizurebasedfactors; (1)本病好发于中、老年,(尤其以老年人为多,同时伴有基础疾病的糖尿病或隐性糖尿病,患者存在不同程度的脑动脉粥样硬化和脑功能受损,局部脑血流的调节功能下降,可能成为癫痫发作的基础因素; (2)therapidonsetofhyperglycemiaandhypertonicstate,canresultinneuronallargedischarge;anotherpolyolmetabolicdisorders,braincellsin
5、glucosebyaldosereductaseintosorbitolandinositol,fructoseincreasedwithreduced,thesefactorscanbecausedbycerebraledema,exacerbationofcerebralpathologicalchanges,induceepilepticseizures: (2)迅速发生的高血糖及高渗状态,可致神经元大量放电;另外多元醇代谢障碍,脑细胞中的葡萄糖经醛糖还原酶转化为山梨醇,果糖增多和伴有肌醇减少,这些因素均可致脑组织细胞水肿,加重脑的病理改变,促使癫痫发作: (3)hasa
6、rguedthatfocalseizuresoftenoccurinbloodglucoseconcentration,becausethecellsandosmoticpressurecausedbythechangesofcelldehydration,thuschangingthecellmembranestabilityandinducedepilepsy; (3)有人认为局灶性癫痫发作常发生在血糖浓度升高时,由于细胞内外渗透压改变造成细胞脱水,从而改变了细胞膜的稳定性而诱发癫痫; (4)studyfound,nonketotichyperglycemiainvivot
7、hreetricarboxylicacidcyclebyinhibitingGABAmetabolism,increasedcerebralenergyconsumption,therebyloweringtheseizurethreshold; (4)研究发现,非酮症性高血糖症时体内三羧酸循环受到抑制,γ-氨基丁酸代谢升高而增加脑能耗,进而降低了癫痫阈; (5)somescholarsproposeglucosemetabolicdisordercausedby
显示全部收起