中药血管抑制剂人参皂苷rg3联合紫杉醇治疗胃癌术后肝转移的研究

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1、万方数据中华医药884学刊第26卷第4期2008年4月中华中医药学刊CHINESEARCHIVES‘OFTRADITIONALCHINESEMEDICINEv01．26NO．4Apr．208中药血管抑制剂人参皂苷R93联合紫杉醇治疗胃癌术后肝转移的研究袁国荣1”，叶再元2(1．浙江中医药大学，浙江杭州310053；2．浙江省人民医院，浙江杭州310014)摘要：目的：探讨中药血管抑制剂人参皂苷R93联合紫杉醇治劳胃癌术后肝转移的临床疗效。方法：39例胃癌术后肝转移患者随机分为治疗组18例，采用中药血管抑制荆人参皂苷a

2、93联合紫杉醇为主化疗，对照组2l例，采用单纯紫衫醇为主化疗。结果：治疗组总有效率(CR+PR)迭66．6％，对照组42．8％。两组比较有显著性差异(P<0．05)；两组治疗后血清血管内皮生长因子(VEGF)均有下降，治疗组下降更明显(P<0．01)；治疗组在保护免疫功能方面优于化疗组，两组比较有显著性差异(P<0．01)；治疗组中位生存期及中位疾病进展时问较对照组延长，两组中住生存期及中位疾病进展时间比较有显著性差异(P

3、免疫功能，延长中住生存期及中位痰病进展时间。关键词：胃肿瘤；肝转移；中药血管抑制荆；人参皂苷R93；紫杉醇中图分类号：R285．5文献标识码：B文章编号：1673—7717(2008)04—0884—03R93combinedwithPaclitaxelChemotherapyonthePatientswithGastricCarcinomaafterSurgeryandLiverMetastasisYUANGuo-ron91一，YEZai．Yuan2(1．ZhejiangChineseMedicalUniversi

4、ty，Hangzhou310053．Zhanzho，China；2．ZhejiangProvincePeopleHospital，H¨gzhou310014，Zhejiang，China)Abstract：0bjective：ToinvestigatetheelinicalbenefitofChinesetraditionalmedicinevasinhibitorGinsenoside(R93)combinedwithPaclitaxelchemotherapyonthepatientswithgastriccar

5、cinomaaftersurgeryandlivermetastasis．Methods：39patientswithgastriccarcinomaandlivermetastasisweredividedinto2groupsrandomly。Amongthem．18patientsreceivedGinsenoside(R庐)combinedwithpaelitaxelchemotherapy，thecontrolgroup，21patientsweretreatedwithpaelitaxelchemothe

6、rapyalone．Results：theoverallresponserateofthetherapygroup(CRandPR)WaS66．6％，whilethecontrolgroupWas42．8％，significantdifferencewasobservedbetweenthetWOgroups(P<0．05)；thelevelofVEGFWaSdecreasedinbothofgroups，whichofthetherapygroupwagobviouslylowerthanthatofthecont

7、rolgroup(P<0．01)；ProtectingimmunityabilityofthetherapygroupWassignificantlyhigherthanthatofthechemotherapygroup(P<0．01)；TherewassignificantdifferencebetweenPFSand耵'Pofthetwogroups(P<0．05)，期限andPFSofthetherapygroupwerelongerthanthatofthecontrolgroup．Conclusion：G

8、insenoside(瞄)combinedwithPaclitaxelehem·otherapytreatsthepatientswithgastriccarcinomaaftersurgeryandlivermetastasiswhichmaybehelpfulinenhancingtheoveralleffectiverate．protec