油菜蜂花粉生理活性及作用机制研究进展

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1、万方数据兰Q!Q!!!：鱼!盟!：2主旦鉴些垒￡!￡型竖型坚量箜．曼地盥垒一一一一．遮验班究揠告§一[文章标号]0412-4367(2010)09—0005—05油菜蜂花粉生理活性及作用机制研究进展孙毅1杨义芳：杨必成：陈琼珊1(1．武汉小蜜蜂食品有限公司，武汉430223；2．上海医药工业研究院，上海200040)摘要：近年来，油菜蜂花粉抗前列腺增生研究取得了突破性进展，明确了所含的长链脂肪酸类、黄酮类、生物碱、脑苷脂类及甾体化合物为抗BPH有效成分群，其中长链脂肪酸类活性最强。油菜蜂花粉抗BPH显示出多成分、多靶点、多环节的特点，特别是对激素的调节和

2、抗炎作用明显，其药效物质基础和作用机制基本得以阐明。黄酮类提取物是油菜蜂花粉抗氧化性的活性物质；油菜蜂花粉多糖通过提高机体IL一2、TNF一仅mRNA的表达而发挥抗肿瘤作用；油菜花粉超临界CO：提取物具有降低高血脂和抗炎的作用。以上的研究成果为油菜蜂花粉深层次开发利用提供了科学依据。关键词：油菜蜂花粉；药理；作用机制；进展[中图分类号]鹃96．4[文献标识码]A‘l●1‘●1●■··‘·’‘^1hAavancesinstudies0nDnVSl0109lCalactivitiesandmechanismsofBeePollenofBrassicacamp

3、estrisSunYilYangYifangzYangBichengzChenQiongshan2(1．WuhanBeeHealthyCO．，LTD．Wuhan430223；2．DepartmentofTraditionalChineseMedicine。ShanghaiInstituteofPharmaceuticalIndustry，Shanghai200040)Abstract：ThisreviewaddressedadvancesinstudiesonphysiologicalactivitiesandmechanismsofBeePoHenof

4、Brassicacampestrisbasedonsummarizationofourmanyyears’researchworkcombinedwithliteraturedata．StudiesonBeePollenofBrassicacampestrisfortreatmentofbenignprostatichyperplasia(BPH)havegot-tengreatprogress．Fattyacidsand?theirderivatives，flavones，alkaloidsandcerebrosidewereconsideredtob

5、etheactiveingredientsofBeePoUenofBrassicacampestr／sfortreatmentofBPH，andlongchainfattyacidsismostactiveconstituent．Malti—components．malti—tragetsandmulti—stepsarecharacteristicofBeePoUenofBrassieacampestrisfortreatmentofBPH．HormonalRegulationandanti—inflammationactivitiesarespeci

6、allyconspicuous．FlavoneextractionisantioxidantactivesubstancesofBeePollenofBrassicacampestris；antitumoreffectofPolysaccharidefromBeePoUenofBrassicacampestrisbasedonenhancementtheexpressionofIL一2、TNF—OtmRNA．ThesupercriticalcarbondioxidefluidextractionfractionofBeePonenofBrassicaca

7、mpestrishavethefunctionofreducingbloodlipidandanti—inflammationactivities．AboveresearchachievementsprovideevidenceforfurtherexploitationandutilizationofBeePollenofBrassicacarnpestris．Keywords：BeePollenofBrassieacampestrisL．var．oleiferaDC．，Pharmacologicalactivities，mechanismofacti

8、on，Advancement研究发现，油菜(Brassicacampestris