蛋白质分子分类及三维建模研究

《蛋白质分子分类及三维建模研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、密级公开分类号０４３＿ＸＶＡＮＴＥＣＨＮＯＬＯＧＩＣＡＬＵＮＩＶＥＲＳＩＴＹＩ硕士学位论文＿题目：蛋白质分子分类及三维建模研究作者：孙素平、指导教师：史小红副教授冯孝周副教授申请学位学科：ｍ２０１８年５月７日密级公开分类号O43XI’ANTECHNOLOGICALUNIVERSITY硕士学位论文题目:蛋白质分子分类及三维建模研究作者：黑体4孙号素平指导教师：史小红副教授冯孝周副教授申请学位学科：光学2018年5月7日型；然后基于X射线衍射原理对血红蛋白和肌红蛋白建立了球棍模型、球体模型、以及卡通模型三种模型

2、，并对其基于5阶harr小波变换进行了比对，研究结果表明：他们的序列存在很大的差异性，从卡通模型中我们可以明显看出两类蛋白质均为单链α类蛋白质，他们的螺旋类型导致了其功能的相似性。关键词：蛋白质分子；蛋白质结构分类；小波变换；结构相似性分析eigenvalueandthehydrophobicvalueoftheproteinisfound.Thecorrelationcoefficientwasrelatedtotheclassificationofproteinstructure.Atlast,theaminoacidsequenceof180setsofproteinswasr

3、andomlydownloadedonPDBwebsite.Theresultsshowedthattheaccuracyoftheclassificationofαtypeandβtypeproteinmoleculesreached89.65%,theaccuracyofthemolecularclassificationofαβtypeproteinsreached92.86%,andtheresultsshowedthatthewaveletanalysismethodiseffectiveinproteinstructureclassification.Finally,mo

4、delingandcomparativeanalysisoftwokindsofstructuralsimilarproteinsareconcerned.Particularly,threedimensionalmodelingandanalysisoftwokindsofproteinswithsimilarstructuresanddifferentsequencesareestablished.Firstly,theproteinanalysismodelofVDWmodel,ballstickmodelanddriftmodelarestudied.Then,basedon

5、theprincipleofXraydiffraction,threemodelsofhemoglobinandmyoglobinareestablished,suchastheballmodel,thespheremodelandthecartoonmodel,andthecomparisonismadeonthe5orderHarrwavelettransform.Asaresult:thereisagreatdifferenceintheirsequence.Fromthecartoonmodel,wecanclearlyseethatalltwokindsofproteins

6、aresinglestrandαtypeproteins,andtheirtypeofhelixleadstothesimilarityoftheirfunction.Keywords:Proteinmolecules;Proteinstructureclassification;Wavelettransform;Structuralsimilarityanalysis目录1绪论........................................................................................................

7、................................11.1引言..................................................................................................................................11.2研究背景及意义...................................................