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1、MethodsinMolecularBiology1716MarcoFondiEditorMetabolicNetworkReconstructionandModelingMethodsandProtocolsMETHODSINMOLECULARBIOLOGYSeriesEditorJohnM.WalkerSchoolofLifeandMedicalSciencesUniversityofHertfordshireHatfield,Hertfordshire,AL109AB,UKForfurthervolumes:http://www.springer.com/se
2、ries/7651MetabolicNetworkReconstructionandModelingMethodsandProtocolsEditedbyMarcoFondiDepartmentofBiology,UniversityofFlorence,SestoFiorentino,Florence,ItalyEditorMarcoFondiDepartmentofBiologyUniversityofFlorenceSestoFiorentino,Florence,ItalyISSN1064-3745ISSN1940-6029(electronic)Metho
3、dsinMolecularBiologyISBN978-1-4939-7527-3ISBN978-1-4939-7528-0(eBook)https://doi.org/10.1007/978-1-4939-7528-0LibraryofCongressControlNumber:2017959614©SpringerScience+BusinessMedia,LLC2018Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthemateria
4、lisconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereaf
5、terdeveloped.Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse.Thepublisher,theauthorsandtheeditors
6、aresafetoassumethattheadviceandinformationinthisbookarebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsortheeditorsgiveawarranty,expressorimplied,withrespecttothematerialcontainedhereinorforanyerrorsoromissionsthatmayhavebeenmade.Thepublisherremainsneu
7、tralwithregardtojurisdictionalclaimsinpublishedmapsandinstitutionalaffiliations.Printedonacid-freepaperThisHumanaPressimprintispublishedbySpringerNatureTheregisteredcompanyisSpringerScience+BusinessMedia,LLCTheregisteredcompanyaddressis:233SpringStreet,NewYork,NY10013,U.S.A.PrefaceTha