大豆异黄酮对心肌梗死大鼠心室重构的影响（英文）

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1、维普资讯http://www.cqvip.com中幽新药与临J末杂志(ChinJNewDrugsClinRPIl1)，20064月，第25卷旃4期·24l·：CLCnumber：1007-7669(2006)04—0241—07EfectofsoybeanisoflavonesonventricularremodelinginducedbymyocardialinfarctioninratsLIYue，YAOMing·hui，LUYing—qing，GONGQin·yan(DepartmentofPharmacology,Shang

2、haiMedicalCollege，FudanUniversity,SHANGHAI200032，China)『KEYWORDS]isoflavones；soybeans；myocardialinfarction；ventricularremodeling；hemodynamics；ratsfABSTRACT]AIM：Toinvestigatetheeffectofsoybeanisoflavones(SI)onventricularremodelinginducedbvmyocardialinfarction(MI)．METHOD

3、S：M1wasinducedbypermanentligationoftheleftanteriordescend-ingcoronaryartery(LAD)inmaleSprague-Dawley(SD)rats．Ratswererandomlydividedintosixgroups：sham-operatedgroup(shamgroup)MImodelgroup，captopril50mg’kg～groupandSI30，90，270mg‘kg～groups．Threehoursaftertheoperation，thed

4、rugsorsolventwereadministratedigqdfor35d．Twenty-fourhoursafterthelastadministration，heartrate(HR)，leftventricularend．diastolicpressure(LVEDP)，peaksystolicleftven-tricularpressure(Peak)，maximalrateofleftventricularpressurerising(+dp／d￡)，maximalrateofleftventric-ularpres

5、suredeclining(一dp／d￡～)andmyocardialmaximalshorteningvelocity(I，)weremeasured．Afterabovehemodynamicparametersweremeasured，heartswereextracted．Theratiooftotalventricleweighttobodyweight(TVW／BW)wascalculated．Myocardialcollagenwasshownwiththecollagen-specificpicrosiriusred

6、stain，myocardialinterstitialcollagenvolumefraction(ICVF)，perivascularcollagenvolumefraction(PCVF)，infarctsize，septalthickness(ST)andleftventriculardiameter(LVD)weremeasuredbyimageanalysissystem．RESULTS：Theinfarctsizeofratsincaptopril．SI90mg·kgandSI270mg‘kggroupswere(31

7、±54)％，(32±3)％，and(31±5)％，respectively，allofwhichweresignificantlysmallerthanthatinMIgroup((38．9±2．9)％，P<0．01)．InMIgroup，TVW／BW，LVD，ICVFandPCVFwereremarkablyincreasedcomparedwiththoseinshamgroup(P<0．01)．TheincreasedTVW／BW，LVD，ICVFandPCVFweresignificantlyreducedbytreatme

8、ntwithcap-topril，SI90mg·kgorSI270mg·kg(Jp<0．01，P<0．05(LVDinSI90mg’kggroup))．Whereas，STofratsinMIgroupwassignificantly