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1、皮肤癣菌(Dermatophytes)主要侵犯角化的皮肤、毛发和指(趾)甲等浅部感染的真菌。引起皮肤癣病,包括手癣、足癣、甲癣、头癣、体癣等。包括表皮癣菌属、毛癣菌属、和小孢子菌属三个属。第34章主要病原性真菌2021/9/21医学微生物学体癣(Tineacorporis):环行红斑,边界水泡,搔痒Tineacorporislesionsonthispatient’sabdomenduetothefungusTrichophytonrubrum.www.hudlegekontoret.no.Skinscrapingstakenfrompatient
2、sin10%KOH,andshowhyphaeundermicroscope.fungiqual-a.de2021/9/21医学微生物学Reversesideof红色毛癣菌(T.rubrum)colony,showingdeepredpigmentwww.hudlegekontoret.noTypicalcigarshapedmacroconidiaofT.rubrumgranulartype.©2006TheUniversityofAdelaideWhite,cottonysurface2021/9/21医学微生物学股癣(Tineacruris)
3、:“jockitch”infectionofthegroin,perianalarea.(Trubrumismostfrequentlyresponsible)2021/9/21医学微生物学指甲癣(Tineaunguium):infectiononthenailsthatthickened,crumblinganddiscolored.nailscanbeclippedandusedforculture.OnychomycosiscausedbyTrichophytonrubrum.(FromHayRJ:Cutaneousandsubcutaneo
4、usmycoses.InAnaissieEJ,McGinnisMR,PfallerMA,editors:Clinicalmycology,NewYork,2003,ChurchillLivingstone.)2021/9/21医学微生物学糠秕bi马拉色菌引起的花斑癣Pityriasis(tinea)versicolorTypicaldepigmentedlesionsseenindark-skinnedindividuals,forexampleinAustralianAborigines.(Pathogen:Malasseziafurfur)©2
5、006TheUniversityofAdelaide角层癣菌2021/9/21医学微生物学Treatment:Localantifungalcream(咪康唑miconazole)ororal伊曲康唑itraconazoleareeffective.Prevention:保持皮肤干燥,远离患者及患病动物2021/9/21医学微生物学此类真菌一般存在于土壤和植物,经创伤部位侵入人体皮下组织。一般只限局部,也可引起深部感染。包括:申克孢子丝菌第二节皮下感染真菌2021/9/21医学微生物学Classiclymphocutaneousformofspor
6、otrichosisdemonstratingachainofsubcutaneousnodulesalongthelymphaticdrainageofthearm.(FromChandlerFW,WattsJC:Pathologicdiagnosisoffungalinfections,Chicago,1987,ASCPPress.Copyright1987,AmericanSocietyofClinicalPathologists.)申克孢子丝菌可引起孢子丝菌病也可引起深部感染。2021/9/21医学微生物学Sporothrixschenck
7、iionSabouraud'sdextroseagargrownat25oCcoloniesaremoistandglabrous,withawrinkledandfoldedsurface. Pigmentationmayvaryfromwhitetocreamtoblack.©2006TheUniversityofAdelaideMicroscopicmorphologyofthemycelialformofSporothrix schenckiiwhengrownonSabouraud‘sdextroseagarat25oC. Noteclu
8、stersofovoidconidia(分生孢子)producedsympodiallyonshortconidiopho