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时间:2018-09-05
《胆囊良恶性病变组织中蛋白基因产物9.5的表达及临床意义.doc》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、胆囊良恶性病变组织中蛋白基因产物9.5的表达及临床意义【摘要】目的研究胆囊腺癌、癌旁组织、慢性胆囊炎组织中蛋白基因产物9.5(PGP9.5)表达及其临床病理意义。方法108例胆囊腺癌、46例癌旁组织和35例慢性胆囊炎切除标本常规石蜡包埋切片,PGP9.5染色方法为EnVisionTM免疫组化法。结果胆囊腺癌PGP9.5表达阳性率(45.4%)和评分(1.94±1.84)明显高于癌旁组织(17.4%,X2=10.83,P<0.01;0.86±1.41,t=3.60,P<0.01)和慢性胆囊炎组织(11.4%,X2=13.06,P<
2、0.01;0.58±1.29,t=4.08,P<0.01);PGP9.5阳性良性病变胆囊上皮均呈中至重度不典型增生。患者年龄≤45岁、腺瘤癌变或高分化腺癌、肿块最大径<2cm、无淋巴结转移和未侵犯周围组织病例PGP9.5表达阳性率及其评分明显低于年龄>45岁、低分化腺癌、肿块最大径≥2cm、淋巴结转移和侵犯周围组织病例(P<0.05或P<0.01)。结论PGP9.5表达可能是反映胆囊腺癌发生、进展和预后的重要生物学标志物,检测胆囊良性病例PGP9.5表达水平对于预防和早期发现胆囊癌可能有重要临床意义。【关键词】胆囊肿
3、瘤慢性胆囊炎蛋白基因产物9.5免疫组织化学AbstractObjectiveTostudytheexpressionofPGP9.5anditsclinicopathologicalsignificancesintissuesofgallbladderadenocarcinoma,pericanceroustissuesandchroniccholecystitis.MethodsImmunohistochemicalmethodwasusedforthedetectionofPGP9.5expressivelevelsinroutinelypa
4、raffin-embeddedsectionsfromthespecimensofgallbladderadenocarcinoma(n=108),pericanceroustissues(n=46)andchroniccholecystitis(n=35).ResultsThepositiveratesandscoresofPGP9.5ingallbladderadenocacrcinoma(45.4%,1.94±1.84)weresignificantlyhigherthanthoseinpericanceroustissues(17.4%,
5、X2=10.83,P<0.01;0.86±1.41,t=3.60,P<0.01)andchroniccholecysitis(11.4%,X2=13.06,P<0.01;0.58±1.29,t=4.08,P<0.01).ThepositiveratesandscoresofPGP9.5weresignificantlylowerinthecasesofaged≤45years,adenomatouscancerationorhigh-differentiatiedadenocarcinoma,maximaldiameter
6、ofmass<2cm,no-metastasisoflymphnode,andno-invasionofregionaltissuesthanthoseintheonesofaged>45years,low-differentiatedadenocarcinoma,maximaldiameterofmass≥2cm,metastasisoflymphnodeandinvasionofregionaltissues.ConclusionTheexpressivelevelsofPGP9.5maybeanimportantmarkerfo
7、rreflectingthecarcinogenesis,progression,biologicalbehaviorsandprognosisofgallbladderadenocarcinoma.TheassayesofPGP9.5expressivelevelsinbenignlesionsofgallbladdermayhaveimportantclinicalvaluesforthepreventionandearly-stagefindingofgallbladdercarcinoma.4Keywordsgallbladderneop
8、lasms;chroniccholecystitis;proteingeneproduct9.5;immunohistochemistr
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