医药学临床医学毕业论文 冷循环射频与手术治疗肝癌的临床研究

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1、湖南师范大学本科毕业论文考籍号：XXXXXXXXX姓名：XXX专业：医药学临床医学论文题目：冷循环射频与手术治疗肝癌的临床研究指导老师：XXX二〇一一年十二月十日【摘要】目的研究比较冷循环射频与手术治疗肝癌的疗效、并发症情况、住院花费、住院天数及生活质量。方法肝癌患者159例，分为两组：肿瘤直径≤5.0cm、单发肿瘤44例，手术治疗29例，冷循环射频治疗15例；肿瘤直径＞5.0cm患者115例，手术治疗54例，冷循环射频治疗61例。冷循环射频治疗采用Col-tipRFTM系统，于超声引导下将集束射频治疗针穿刺进入肿瘤进行治疗。分组比较两种治疗的肝功能、

2、AFP改变、并发症情况、住院天数及花费、生活质量评分等。描述影像学变化。结果冷循环射频治疗对患者肝脏功能的破坏小于手术治疗。冷循环射频治疗和手术治疗对患者AFP水平的影响没有明显差异。冷循环射频治疗并发症发生率，住院天数及花费低于手术治疗，术后生存质量高于手术治疗。肿瘤直径≤5.0cm、单发肿瘤，冷循环射频和手术1年生存率及中位生存时间没有差异。结论相对于手术，冷循环射频治疗也是一种安全，有效的肝癌治疗方法。【关键词】射频手术肝癌生活质量Clinicalstudyoftheapplicationofradiofrequencyablationandop

3、erationontreatmentoflivercancer【Abstract】ObjectiveToprobeintothetreatmenteffect，complicationsrate，lifequalityandhospitalizationexpensesofapplyingradiofrequencyablation(RFA)totreatlivercancerandcomparetowhichoftheoperation.Methods159livercancerpatientswereincludedinthisstudy.They

4、weredividedintotwogroupsaccordingtothediametersoftheirtumorsandwhethertheirtumorsweresolo.Among44casesinthegroupofsolotumorwithtumordiametersequalandlessthan5.0cm，29casesreceivedoperationsand15receivedradiofrequencytreatments，among115casesofthegroupwithtumourdiametersmorethan5.0

5、cm，54casesreceivedoperationsand61receivedradiofrequencytreatments.Theoperationswerehepatolobectomy.Radiofrequencytreatmentwereconductedeitherpercutaneouslyorintraoperativelyundertheguidanceofultrasound.Thebundledneedleswerepuncturedintothetumorsandperformedradiofrequencytreatmen

6、ts，withtreatmentfrequencyof480kHz，treatmenttime12min.Collecteddataofliverfunction（ALT，ALB，TB），AFP，complications，hospitalizationdaysandexpensesofpatientsreceivingoperationsandradiofrequencytreatmentsrespectively，observedchangesinradiology.Differencesbetweentheabove-mentioneddatao

7、fpatientsreceivedoperationsandradiofrequencytreatmentswithintwogroupswerecompared.ResultsThedamagingeffectofliverfunctionofradiofrequencytreatmentwaslessseverethanoperations.TherewasnosignificantdifferencebetweentheAFPchangesofpatientsreceivedradiofrequencytreatmentandthoserecei

8、vedoperations.Concerningcomplications，hospitali