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1、急性冠脉综合征患者血清炎性指标及肌钙蛋白I的临床研究【摘要】 目的 研究急性冠脉综合征患者（ACS）血清炎性指标的水平与肌钙蛋白I的关系及临床意义。方法 测定冠脉造影阳性的ACS患者74例、稳定型心绞痛（SAP）患者58例和造影阴性的冠心病患者46例（对照组）血清超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)、可溶性P-选择素(sP-sel)和肌钙蛋白I(cTnI)的水平，并采集相应的各项临床资料。结果 ACS组患者血清各项炎性指标分别为hs-CRP(7.40±2.90)mg/L、IL-6(235.62±87.03)ng/L
2、、sP-sel（87.82±36.02）mg/L、cTnI(4.38±3.85)mg/L,高于SAP组患者和对照组，差异均有统计学意义（t分别=6.52、4.94、2.97、7.23、8.96、5.63、3.32、8.67，P均＜0.05）；cTnI增高患者各血清炎性指标分别为hs-CRP(8.74±1.61)mg/L、IL-6(265.33±66.62)ng/L、sP-sel（99.43±25.42）mg/L,明显高于cTnI正常者，差异均有统计学意义(t分别=4.59、3.92、3.65,P均＜0.05)。结论 血清炎性指标在ACS
3、患者中均表现为增高。cTnI与血清各项炎性指标具有相关性。cTnI及血清各项炎性指标与冠脉内斑块的不稳定状态具有相关性。【关键词】急性冠脉综合征炎性指标肌钙蛋白I ClinicalresearchonserumlevelsofinflammatoryindicatorsandcardialtroponinIinpatientswithacutecoronarysyndromeLINJianping,WUGuohua.CenterofClinicalLaboratory，WuyiFirstPeople'sHospital,Wuyi321
4、200,Ｃｈｉｎａ ＡｂｓｔｒａｃｔＯｂｊｅｃｔｉｖｅToexplorerelationshipandclinicalsignificanceofserumlevelsofinflammatoryindicatorsandcardialtroponinIinpatientswithacutecoronarysyndrome(ACS).MethodsSerumlevelsofhighsensitivityCreactiveprotein(hs-CRP),interleukin-6(IL-6),solubilityP-selectin(s
5、P-sel),cardialtroponinI(cTnI)in74casesofpositivecoronaryvisualizationpatientswithACS,58casesofpatientswithstableanginapectoris(SAP)and46casesofnegativecoronaryvisualizationpatientswithcoronaryheartdisease(CHD)（controlgroup）weredetermined.Relatedclinicaldataofthesepatient
6、swereanalyzed.ResultsTheserumlevelsofinflammatoryindicatorsofpositivecTnIpatientswerehs-CRP(8.74±1.61)mg/L；IL-6(265.33±66.62)ng/L；sP-sel（99.43±25.42）mg/L.AndthoseofACSgroupwerehs-CRP（7.40±2.90）mg/L；IL-6(235.62±87.03)ng/L；sP-sel（87.82±36.02）mg/L;cTnI(4.38±3.85)mg/L.Theser
7、umlevelsofeachinflammatoryindicatorsofpatientsinACSgroupweresignificantlyhigherthanthatofpatientsinSAPgroupandcontrolgroup(t=6.52,4.94,2.97,7.23，8.96,5.63,3.32,8.67,P<0.05).TheserumlevelsofeachofinflammatoryindicatorsofpositivecTnIpatientswas5significantlyhigherthanth
8、atofnegativecTnIpatients(t=4.59,3.92,3.65,P<0.05).ConclusionsTheserumlevelsofeachofinflammatoryindic
