弥漫性掌跖角化症合并指节垫一家七例.docx

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1、类天疱疮和天疱疮患者肿瘤坏死因子α及可溶性肿瘤坏死因子Ⅰ型受体的测定类天疱疮和天疱疮患者肿瘤坏死因子α及可溶性肿瘤坏死因子Ⅰ型受体的测定中华皮肤科杂志1999年第6期第32卷论著作者：陈向东　翁孟武　陈洪　苏玮　侯爱琴单位：陈向东　200011上海第二医科大学附属第九医院皮肤科；翁孟武（指导者）　苏玮　侯爱琴　上海医科大学附属华山医院皮肤科；陈洪　上海第二医科大学微生物教研室关键词：类天疱疮；大疱性天疱疮肿瘤坏死因子受体；肿瘤坏死因子【摘要】目的　探讨肿瘤坏死因子α(TNFα)及其可溶性Ⅰ型受体(sTNF-RⅠ)在类天疱疮（BP）、天疱疮（PV

2、）患者疱液和血清中的变化及其临床意义。方法　应用ELISA方法对比研究31例BP、9例PV患者血液和疱液中TNFα和sTNF-RⅠ的含量。并以15例正常人吸疱液和30例正常人血清作对照。结果BP、PV患者活动期疱液和血液中sTNF-RⅠ水平均高于对照，且疱液中浓度更高；BP缓解初期血中sTNF-RⅠ水平高于活动期；BP患者血液和疱液中均未测到或有极少量TNFα，PV患者血液中仅测到低浓度的TNFα，而疱液中TNFα浓度明显高于对照。结论　细胞因子sTNF-RⅠ和TNFα可能参与了BP和PV的发病，sTNF-RⅠ在BP中可能对机体起保护作用，有望

3、成为病情好转和治疗有效的新的观察指标。LevelsofTumourNecrosisFactorαandItsSolubleReceptorTypeⅠinSeraandBlisterFluidsofPatientswithAutoimmuneBullousDermatosesCHENXiangdong,WENGMengwu,CHENHong,etal.DepartmentofDermatology,HuashanHospitalofShanghaiMedicalUniversity,Shanghai200040【Abstract】Objectiv

4、e　Todeterminetherelationshipbetweentumournecrosisfactorα(TNFα)anditssolublereceptortypeⅠ(sTNF-RⅠ)andtheirsignificanceinautoimmunebullousdermatoses.MethodsThelevelsofTNFαandsTNF-RⅠinbothseraandblisterfluidsof31caseswithbullouspemphigoid(BP)and9caseswithpemphigusvulgaris(PV)we

5、reinvestigatedbyELISA.Fifteensuctionblisterfluidsand30serafromnormalinpidualsweretakenasthecontrol.ResultsAtactivestage，thelevelsofsTNF-RⅠwerehigherinboththeseraandblisterfluidsfrompatientswithBPandPVthanthosefromthecontrols,andweremuchhigherinblisterfluidsthaninsera.Theseru

6、mlevelofsTNF-RⅠwasevenhigheratearlyremissionstagethanatactivestageofBP.ThereweretracesorundetectableamountofTNFαinbothseraandblisterfluidsofBPcases.TNFαlevelwasmuchlowinseraofPVcases,buthigherinPVpatients′blisterfluidsthanincontrolgroup′s.ConclusionsTNF-RⅠandTNFαmightberelat

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