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1、MHC &marrowtransplantationMHCandMarrowTransplantationHistoryBasicdefinitionPrincipleandprocessesofMHCandmarrowtransplantationProblemswearefacingtodayThemethodweexcogitateHISTORYHISTORYThefirsttransplantationiscorneatransplantation，ithasahistoryof200years。1824,Reisingerfirstlydesignedcorneatransplan
2、tationsurgery.JosephMurryfirstlytransplantedkidneybetweentwotwinsin1954.1968,thefirstbonemarrowtransplantationsucceeded.ReisingerUptonow,thenumberoftransplantationforheart,liver,kidneyhasreached500,000allovertheworld.During2006,over9500patientsreceivedmarrowtransplantation.Transplantationbeganfrom1
3、960sinChina,anditdevelopsrapidly.DefinitionMHC：Alargeclusteroflinkedgeneslocatedinsomechromosomeinhumanorothermammalsrelatetoimmuneresponseandimmuneregulation.MHCmolecule:AgroupofproteinencodedbyMHCplayinganimportantroleinhumanimmunity,theycanbedividedintotwokinds——MHC-Ⅰ，MHC-ⅡBonemarrowtransplantat
4、ionTreatthepatientswithleukemiaorsimilardiseasethroughreplacinghis/herbadbonemarrowbyhealthyoneThepatientsmustacceptchemotherapyorradiotherapytodestroythetumorandunhealthybonemarrowPrincipleandProcesses of MarrowTransplantationGeneralconditionsofMHCmoleculeMHC-Ⅰmolecule※encodedbythesixthandfifteent
5、hchromosome※composedoftwochains:άchain(heavychain),βchain(microglobulin)※dividedintofourdomains:ά1,ά2,ά3,β2mtworegions:peptidebindingregion,immunoglobulin-likeregion※distribution:allnucleatedcellsMHC-Ⅱmolecule※encodedentirelybythesixthchromosome※composedoftwochains:άchain,βchain※dividedintofourdoma
6、ins:ά1,ά2,β1,β2tworegions:peptidebindingregion,immunoglobulin-likeregion※distribution:professionalantigen-presentingcells,thymusepithelialcells,activatedTcellsά1ά2β1β2PlasmamembranePropertiesofMHCmolecule※HaplotypeHeredity※LinkageDisequilibrium※Polymorphismdifferenceofindividual inimmunologydifficu
7、ltyofTissueTypingFunctionofMHCmolecule※InducingmaturationofTcellspositiveselectionnegativeselection※PresentingantigensfortherecognitionofTCR※InvolvedintransplantationrejectionEarly“BoneMarrowTransplantation
