资源描述：
《嘧菌酯中间体邻氰基苯酚的合成（synthesis of an intermediate of n, n, p, n, p, p, m）》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、嘧菌酯中间体邻氰基苯酚的合成（SynthesisofanintermediateofN,N,P,N,P,P,M）SynthesisofanintermediateofN,N,P,N,P,P,MChenJiangAbstract:O-cyanophenolaspharmaceuticalandpesticideintermediates,therecentdiscoveryoffungicideazoxystrobinwasusedasanintermediaterawmaterial,azoxystrobinfungicide
2、shasdevelopedintotheworld'sbiggestselling,sointermediateadjacentcyanophenolhasbroadmarketprospects.Thispaperadopts2-hydroxybenzaldehydeasstartingmaterials,andthereactionofhydroxylaminesulfateinthepresenceofsodiumformateandformicacid,havehighcontentofO-cyanophenol,th
3、istechnologyissimpleandmature,cancarryoutindustrialproduction.Keywords:O-cyanophenol,azoxystrobin,intermediatesOrthocyanophenolcanbeusedasapharmaceuticalandpesticideintermediate,andthemostrecentlydiscoveredmethoxyacrylatefungicideazoxystzobinisusedasrawmaterial.Azox
4、ystrobinhasdevelopedintotheworld'sbiggestsellingbactericide,itiswidelyusedincereals,rice,grapes,potatoes,vegetablesandfruittrees,thepreventionandcontrolofalmostallfungaloomycetediseasessuchasrust,powderymildew,netblotch,scabetc..Atpresent,thereisnoproductionandnores
5、earchreportsonthisproduct.Wehavemadeadetailedstudyonthisproduct.Chemicalname:O-cyanophenol,orthohydroxybenzonitrileCAName:Benzonitrile2-hydroxy,subjectindexCASaccessionnumber:[611-20-1]Structuralformula:Molecularformula:C7H5NOMolecularweight:119.12Physicalandchemica
6、lproperties:whitesolid,M.P.96-98Thesyntheticprincipleof1.orthocyanophenolThechemicalstructureoforthocyanophenolisrelativelysimple,andthefollowingsyntheticroutesarereportedintheliterature:1.1methodsoneInthepresenceofsodiumacetateandaceticacid,orthohydroxybenzaldehyde
7、andnitroethanereactwith(Synthesis1985,(5),510-512;C.A.104,206854f)Therearealsoreactionsoforthobenzaldehydeandnitroethaneinthepresenceofanhydrouspyridinehydrochloride(Synthesis1981,739)1.2methodtwoInthepresenceofsodiumformateandformicacid,orthohydroxybenzaldehydeandh
8、ydroxylaminesulfatereactedwith(Ger.2014984;C.A.76,P14143e)Therearealsoreactionsofsodiumorthophthalateandhydroxylaminehydrochlorideinthepre
