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1、高能射线对腮腺功能的影响及机理初探刘英杰2胡国清郑艳1430030武汉市华中科技大学同济医院肿瘤中心2467000济南军区第152医院肿瘤科（通讯作者：刘英杰）郑有合景琴唐曦潘鲁黄乔刘佳其1430030武汉市华中科技大学同济医院肿瘤科2467000济南军区第152医院肿瘤科（通讯作者：刘英杰）目的：初步探讨高能射线对腮腺功能的影响及其机理，为头颈部肿瘤放疗后口腔干燥治疗提供理论基础。方法：年满4月大梅杂交猪8头，4头双侧唾液腺造瘘，15MV-X线单侧腮腺照射，5Gy/次，3次/W，总量40Gy/
2、8次/16d，为实验组；对侧未照射腮腺为自身对照组；2头单纯造瘘为阴性对照组；余下2头不做任何处理，为病理对照组。观察照射动物临床征象变化；每日记录唾液总量，采用SPSS11.0最小显著性差异（LSD）检验比较实验组、自身对照组、阴性对照组分泌量差异；2月后取腮腺病理学检查，比较4组腮腺显微结构变化。结果：照射猪饮食下降、进食期间频繁饮水；照射组于13±2d起分泌明显减少，LSD处理显示试验组、自身对照组、阴性对照组间两两比较均有显著差异。病理学检查显示，照射腮腺总体结构尚存，细胞排列轻度紊乱，
3、细胞数目无明显减少，部分胞核增大，胞浆相对增加，凋亡细胞少见，有区域分布趋势，自身对照组与阴性对照组腺体结构无明显变化。结论：辐射对唾液分泌的影响除细胞凋亡原因外，可能尚有其它重要机制。关键词：高能射线唾液分泌影响TheinvestmentoftheeffectsofhighenergyXrayontheslivaryfunctionandthepilotstudyofitsmechenism.LIUYingjie,HUGuoqing,ZHENGyouhe,etal.Thedepartmento
4、ftumour,The152hospitalofPLA.Henan,467000,China.Abstract:ObjectiveToinvesttheeffectsofhighenergyXrayontheslivaryfunctionanditsmechanism,aimstoprovideguidanceforthetreatmentofxerostomiacausedbysalivaryirradiationinjury.MethodFistulizationofsalivaryduct
5、swasoperatedonbothsidesofthethreeamongthe8DameiHybridizationswine,whichagesrangesfrom4to5months,4oftheswineswereadministeredradiationonhalfsidesalivaryglandsby15MV-Xray,5Gypertime,3timesaweek,8timesaddupto40Gy,asradiatedgroup.Thecontralateralparotids
6、weretakenasself-controlgroup;Theother2swinesweremerelyfistulated,asnegativegroup;And2swinesweretakennodisposal,aspathologicalcontrolgroup.Recordthesialonamounteachdaycontinuously,Theleastsignificantdifference(LSD)ofSPSS11.0wasusedtoshowthedifferenceo
7、fsialonamount.2monthslater,pathologicalexaminationwasperformedtotheparotidglandsofeachswine.Result:Theirradiatedswineshowedlowerdiet,drinkingfrequentlywhileeating;13±2ddaysfromthebeginningofirradiation,theirradiatedparotidexhibitsdecreasinginsecretio
8、n,whilethecontralateralparotidincreasingalittle;Pathologicalexaminationshowsnomuchchangesincellnumbersoftheirradiatedsalivary,comparetotheunirradiatedparotidgland;Theapoptosisofcellsincrease,andhavethetendencyofregionaldistribution.ConclusionTheeffec
