双歧杆菌乳杆菌三联活菌片防治小儿抗生素相关性腹泻的临床研究

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1、双歧杆菌乳杆菌三联活菌片防治小儿抗生素相关性腹泻的临床研究【摘要】目的探讨双歧杆菌乳杆菌三联活菌片防治小儿抗生素相关性腹泻(AAD)的临床疗效。方法选取2010年3月至2013年2月本院呼吸道感染患儿300例，首先按照年龄大小分为A组(1个月～1岁)140例，B组(1～3岁)160例，AB两组内再随机分成观察组150例(A组:70例，B组:80例)与对照组150例(A组:70例，B组:80例)。对照组应用抗生素治疗呼吸道感染，出现腹泻后给予常规治疗;观察组在应用抗生素治疗的同时给予双歧杆菌乳杆菌三联活菌片，出现腹泻后在常规治疗的基础上继续

2、服用该药物。观察指标包括腹泻发生率、治疗总体有效率、腹泻持续时间三项。结果①观察组腹泻发生率明显的低于对照组，腹泻治疗总体有效率明显的高于对照组，腹泻持续时间明显的短于对照组，差异有统计学意义(P＜0.05);②B组中观察组的腹泻发生率明显低于A组中的观察组，差异有统计学意义(P＜0.05)。结论双歧杆菌乳杆菌三联活菌片防治小儿抗生素相关性腹泻临床疗效显著，尤其对于1～3岁的小儿AAD预防效果更加突出，值得临床推广。【关键词】双歧杆菌乳杆菌三联活菌片;抗生素相关性腹泻;小儿TheclinicalresearchOfpediatricant

3、ibioticassociateddiarrheapreventedandtreatedbybifidobacteri-umlactobacillustriplelivingbacteriumtabletQUShu-sheng．ShandongFeichengMiningCenterHospital，Tai’an271608，China【Abstract】ObjectiveDiscusstheclinicaleffectofpediatricantibioticassociateddiarrhea(AAD)pre-ventedandtre

4、atedbybifidobacteriumlactobacillustriplelivingbacteriumtablet．MethodsSelectionourhos-pitalpediatricrespiratorytractinfectionchildren300casesfromMarch2010toFebruary2013，firstlydividedintogroupA(1month～1yearold)140casesandgroupB(1～3yearold)160casesaccordingtotheage;secondly

5、randomlydividedintoobservationgroup(groupA:70casesandgroupB:80cases)andcontrolgroup150cases(groupA:70casesandgroupB:80cases)withintheABgroups．Controlgroupgivenantibioticstreatrespiratorytractinfection，givenconventionaltreatmentafterdiarrheaappear;Observationgroupgivenbifi

6、dobacteriumlactobacillustriplelivingbacteriumtabletatthetimeofapplicationofantibiotics，continuetak-ingthisdrugonthebasisofconventionaltreatmentafterdiarrheaappear．Observationindexesincludingthein-cidenceofdiarrhoea，totaleffectiverate，durationofdiarrhoea．Ｒesults①Theinciden

7、ceofdiarrheaofobser-vationgroupwasobviouslylowerthanthecontrolgroup，diarrheatreatmentoveralleffectivenessobvioushigherthancontrolgroup，thedurationofdiarrheasignificantlyshorterthanthecontrolgroup，withsignificantdiffer-ence(P＜0.05);②theIncidenceofdiarrheaofobservationgroup

8、ingroupBwasobviouslylowerthantheob-servationgroupingroupA，withsignificantdifference(P＜0.05)．Conc