升清胶囊对胆囊胆固醇结石小鼠模型生化学指标的影响

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1、升清胶囊对胆囊胆固醇结石小鼠模型生化学指标的影响【摘要】观察疏肝利胆中药升清胶囊对胆囊胆固醇结石小鼠生化学指标的影响。方法：38只C57BL/6J雌性小鼠随机分为正常对照组(n=10)、模型组（n=15）和升清胶囊组(n=13)。除正常对照组外，模型组和升清胶囊组小鼠采用高脂饮食诱发法建立胆固醇结石模型。造模过程中，升清胶囊组小鼠予升清胶囊0.22g/(kg·d)灌胃治疗。8周后观察各组小鼠的成石率、血脂含量、血清钙离子浓度、肝脏丙二醛（malondialdehyde，MDA）含量及超氧化物歧化酶（superoxidedismutase，SOD）活性。结果：模型组成石率为73.33%

2、，明显高于正常对照组和升清胶囊组，差异有统计学意义（P<0.01）。升清胶囊组血清总胆固醇和低密度脂蛋白含量低于模型组（P<0.01），高密度脂蛋白含量高于模型组（P<0.01）；升清胶囊组小鼠肝脏SOD活性升高和MDA含量下降，与模型组比较，差异有统计学意义（P<0.05）。结论：升清胶囊可通过降低小鼠胆固醇结石模型成石率，改善血清和肝脏的生化学相关指标，从而发挥防治胆石病的作用。【关键词】升清胶囊胆固醇结石小鼠胆固醇丙二醛超氧化物歧化酶ZhangXL,LiangXQ,GuHG,MaEW,LinTB,SunX,ZhangJZ.15JChinIntegrMed

3、/ZhongXiYiJieHeXueBao.2008;6(10):10451048.ReceivedApril10,2008;publishedonlineOctober15,2008.Freefulltext(PDF)isavailableatwww.jcimjournal.com.Indexed/abstractedinandfulltextlinkoutatPubMed.ForwardlinkingandreferencelinkingviaCrossRef.DOI:10.3736/jcim20081011OpenAccessEffectsofShengqingCapsul

4、eonbiochemicalparametersinmicewithcholesterolgallstoneXuelinZHANG1,XiaoqiangLIANG2,HonggangGU1,EnweiMA1,TianbiLIN1,XunSUN1,JingzheZHANG11.DepartmentofHepatobiliarySurgery,LonghuaHospital,ShanghaiUniversityofTraditionalChineseMedicine,Shanghai200032,China152.InstituteofChineseTraditionalSu

5、rgery,LonghuaHospital,ShanghaiUniversityofTraditionalChineseMedicine,Shanghai200032,ChinaObjective:ToobservetheeffectsofShengqingCapsule(SQC),acompoundoftraditionalChineseherbalmedicine,onbiochemicalparametersinC57BL/6Jmicewithcholesterolgallstone.Methods:ThirtyeightC57BL/6Jmicewererandomlydiv

6、idedintonormalcontrolgroup(n=10),untreatedgroup(n=15)andSQCgroup(n=13).Cholesterolgallstonewasinducedinmiceofthelattertwogroupsbyfeedinghighcholesteroldiet.MiceintheSQCgroupwereintragastriclyadministeredSQC0.22g/(kg·d).After8weektreatment,animalsweresacrificedandsampledtocalculatetheincidences

7、ofstoneformation.ThecontentsofserumcholesterolsandCa2+,andthemalonaldehyde(MDA)contentandsuperoxidedismutase(SOD)activityinlivertissuesweredetected.Results:Theincidencesofstoneformationwere73.33%inuntreatedgroup,0%innormalcontrolg