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1、左旋氨氯地平和贝那普利对老年单纯收缩期高血压患者动态血压的影响【关键词】左旋氨氯地平贝那普利老年单纯收缩期高血压动态血压［Abstract］ObjectiveToevaluatetheefficacyoflevomlodipinandbenazeprilon24hdynamicbloodpressure(ABPM)inelderlypatientswithmildtomoderateisolatedsystolichypertension(ISH).MethodsSixtyelderlypatientswhoseaverageagew
2、as64yearsoldwithISHwererandomlydividedintotwogroupsandweretreatedwith5mg/dlevomlodipine,10mg/dbenazeprilrespectivelyfor4weeks.ThechangesofABPMwerecomparedbeforeandfourweeksaftertreatment.Results(1)After4weekstreatment,thereweresignificantdifferencesinloweringsystolicblo
3、odpressure(SBP),andpulsepressure(PP)inthetwogroupsrespectively.Thetotalaveragesystolicanddiastolicbloodpressuredecreasedby(17.03±8.55)mmHg(P<0.001)and(4.83±4.82)mmHginthelevomlodipinegroup,by(14.30±7.26)mmHg(P<0.001)and(4.97±2.87)mmHginthebenazeprilgroup.24hmeanbl
4、oodpressure(MAP)decreasedby(8.86±4.76)mmHg(P<0.001)inlevomlodipinegroup,decreased(8.74±3.07)mmHg(P<0.001)inbenazeprilgroup.(2)PPdecreasedby(16.97±14.06)mmHg(P<0.001)in11thelevomlodipinegroup,by(8.33±7.84)mmHg(P<0.001)inthebenazeprilgroup.(3)Bothdrugsweresimi
5、larlyeffectivein76.7%patientsand73.3%patientsrespectively(P=0.766),andgoalbloodpressurewasachievedin66.7%patientstreatedwithlevomlodipin,56.7%withbenazepril(P=0.426).(4)Theincidenceofdrugrelateddependentsideeffectswere6.67%inthelevomlodipinegroup,16.67%inthebenazeprilgr
6、oup.Conclusion(1)ThedatashowthatbothlevomlodipinandbenazeprilcansignificantlydecreaseSBP,MAPandPP.Therearenosignificantdifferencesinloweringbloodpressurebetweentwogroups.(2)Levomlodipin5mg,andbenazepril10mgoncedailyiseffectiveandsafeinpatientswithmildtomoderatehypertens
7、ion.［Keywords］levomlodipine;benazepril;pharmacologicaction;isolatedsystolichypertension;elderly;dynamicbloodpressure老年人最常见的高血压是单纯收缩期高血压（isolatedsystolic11hypertension,ISH)，约占老年高血压的79.01%。60岁以上的老年群体中ISH所致的心脑血管并发症和死亡日益受到重视,已肯定是冠心病、脑卒中的独立危险因素之一,其发病率为11.7%［1］。多组研究资料证明，收缩压升高
8、的危险性高于舒张压升高。而心脑血管事件的降低首要是心脏病防治研究工作。国内对高血压综合治疗的报道较少,为了提高ISH的控制率,找出更有效的治疗方法,本研究应用24h动态血压监测(ambulatorybloodpressu
