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1、安蓝风湿药液急性毒性实验和镇痛作用的研究作者:曾泽民,李雪艳,肖祥书;潘善庆,陈子渊【摘要】目的(1)观察小鼠口服安蓝风湿药液所产生的急性毒性反应及死亡情况,为临床试验安全性提供资料。(2)通过对小鼠镇痛实验观察,对临床用药提供依据。方法(1)经10只小鼠预试,ig测不出LD50,故进行最大给药量测定。(2)对醋酸致痛小鼠扭体次数的影响;对热板法致痛小鼠痛阈的影响。结果(1)小鼠ig安蓝风湿药液每日最大给药量为180g生药/kg相当于临床60kg成人一日量的400倍;(2)安蓝风湿药液高、中、低三个剂量组和阿司匹林阳性对照组均明显抑制醋酸致痛小
2、鼠扭体次数的增加,均能明显提高给药后30、60、90、120min热刺激小鼠的痛阈值,其中安蓝风湿药液高、中剂量组和阿司匹林阳性组均能明显提高醋酸致痛小鼠扭体的替伏期。结论(1)安蓝风湿药液毒性小,在临床推荐的用药剂量下使用是安全的;(2)安蓝风湿药液具有明显的镇痛作用。【关键词】安蓝风湿药液;急性毒性试验;镇痛实验ResearchontheacutetoxictestandtheanalgesiaeffectoftheAnlarfengshisolution8【Abstract】Objective(1)Observationmicewitho
3、ralAnlanfengshisolutionproducesacutetoxicresponseanddeathsituation,providesthematerialfortheclinicaltestsecurity.(2)Throughmiceanalgesiaexperimentobservation,providesthebasiswiththemedicine.Method(1)After10micepreparations,igcannotmeasureLD50,thereforecarriesonsurveyquotafor
4、mostgreatlygivesthedoses.(2)Toaceticacidcausestheachemiceswaysfromsidetosidethebodynumberoftimes;OfRebanmethodcausestheachemouseachescopeinfluence.Results(1)MiceigAnlanfengshisolutionmostgreatlygivesthedoseeverydayis180gdrugs/kg,equaltoclinical60kilogramsgrown-uppersoneveryd
5、ayamountused400times;(2)Anlanfengshisolutionhigh,middle,smallerthreeamountusedwithaspirintabletspositivecomparisongroupallobvioussuppressiontheaceticacidcausestheacheofthemouseswaysfromsidetosidethebodilynumberoftimestheincrease,allcanobviouslyenhancefordrugsafter30th,60,90,
6、120min.Theheatstimulatesmouse’spainthresholdvalue,amongAnlanfengshisolutionhigh,middleamountusedwithaspirintabletspositivecomparisongroupallcanobviouslyenhancetheaceticacidcausestheachemouseswaysfromsidetosideofthe8bodyforbendsdownthetime.Conclusion(1)Anlanfengshisolutiontox
7、icityissmall,usesunderthemedicinedosageintheclinicalrecommendationtheuseissafe;Anlanfengshisolutionpossessobviousanalgesiafunction.【Keywords】Anlanfengshisolution;acutetoxicitytest;analgesiaexperiment安蓝风湿药液是邵阳市中医医院经多年临床观察治疗“风寒湿痹”具有显著疗效的中药方剂。“风寒湿痹”[1]是采用病因分类的方法,是“五因痹”中风痹、寒痹、湿痹
8、的合称,不包括热痹、燥痹。其病因是正虚、邪侵、痰瘀三大主要因素,病机相当复杂,常有“虚”、“邪”、“痰”相互搏结,“不通”、“不荣”同时并见。方中以鬼