姜黄素对高脂血症大鼠txb2、6-keto-pgf1α的影响

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1、姜黄素对高脂血症大鼠TXB2、6-Keto-PGF1α的影响作者：孙玉凤陈志强丁奇峰尹智炜李红霞方敬【摘要】目的观察姜黄素对高脂血症大鼠血栓素B2(TXB2)、6-酮-前列腺素F1α(6-Keto-PGF1α)的影响，探讨其延缓动脉粥样硬化形成的可能机制。方法60只大鼠随机分为正常组、模型组、辛伐他汀组、姜黄素组。正常组喂饲普通饲料，其他3组喂饲高脂饲料，共4周。第5周开始，姜黄素组、辛伐他汀组分别灌服姜黄素0.571g/(kg·d)、辛伐他汀5.71mg/(kg·d)；正常组和模型组灌以相应剂量的0.9%氯

2、化钠注射液，共6周。至10周末，取静脉血检测TXB2、6-Keto-PGF1α的水平。结果模型组大鼠血浆TXB2含量明显升高(P<0.01)，6-Keto-PGF1α含量显著降低(P<0.01)。辛伐他汀组、姜黄素组与模型组比较，血浆TXB2水平明显下降(P<0.01)，血浆6-Keto-PGF1α水平明显上升(P<0.01，P<0.05)；辛伐他汀组与姜黄素组比较，血浆TXB2水平无统计学意义(P>0.05)，血浆6-Keto-PGF1α水平姜黄素组高于辛伐他汀组(P&l

3、t;0.01)。结论姜黄素可增加前列环素含量，减少缩血管物质TXA2的分泌，防止血栓形成，延缓动脉粥样硬化的形成。【关键词】姜黄素；高脂血症；血栓烷B2；6-酮-前列腺素F1α8；降血脂药(中药)；胶囊剂　　TheeffectofJianghuangsuonTXB2、6-Keto-PGF1αontheexperimentalhyperlipidemicrats　　【Abstract】ObjectiveToobservetheeffectofJianghuangsuonThromboxaneB2(TXB2)、6

4、-Keto-PGF1αtoinvestigateitsprobablemechanismofaction.Methods60ratsusedinthisinvestigationwererandomlydividedintofourgroups:15innormalgroup,15inthemodelgroup15inthesimvastatingroupand15inJianghuangsugroup.Thenormalcontrolgroupwasfedwithnormaldiet,andotherthr

5、eeexperimentalgroupswithhigh-fatdietfromthefirstdayoftheexperimentforfourweeks.Thedrugswereadministratedbygavagefromthebeginningofthefifthweek.TheJianghuangsugroupwereadministratedwithJianghuangsu(0.571g·kg-1·d-1),simvastatingroupwereadministratedwithsimvas

6、tatin(5.71mg·kg-1·d-1).Normalsalinewasgiventoratsofnormalcontrolgroupandmodelgroup(0.571g·kg-1·d-1).Eachgroupwasgivengavageforsixweeks.Attheendingofthetenthweek,todetectthelevelofTXB2、6-Keto-PGF1α.ResultsComparedwithnormalgroup,theTXB2contentinmodelgroupwas

7、significantlyincreased(P<0.01),andthe6-Keto-PGF1αcontentwas8significantlydecreased(P<0.01).Comparedwithmodelgroup,theTXB2contentsintwotreatmentgroupsweresignificantlydecreased(P<0.01),andthe6-Keto-PGF1αcontentsweresignificantlydecreased(P<0.05).

8、Intwotreatmentgroups,theTXB2contentshadnodifference(P>0.05),and6-Keto-PGF1αcontentofJianghuangsugroupwashigherthanthatofsimvastatingroup(P<0.01).ConclusionJianghuangsucouldhavetheeffectsofanticoa