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ID:15185146
大小:36.00 KB
页数:10页
时间:2018-08-01
《mppe的荧光素和吲哚青绿眼底血管造影的临床特征及意义》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、MPPE的荧光素和吲哚青绿眼底血管造影的临床特征及意义作者:周才喜,李瑞峰,苑志峰,张胜娟【摘要】 目的:观察多发性后极部色素上皮病变(multifocalposteriorpigmentepitheliopathy,MPPE)的荧光素眼底血管造影(fundusfluoresceinangiography,FFA)和吲哚青绿眼底血管造影(indocyaninegreenangiography,ICGA)特征及其临床意义。方法:回顾性分析200701/200904期间在我院就诊的35例51眼MPPE患者的临床资料。所有患者都接受了常规视力、裂隙灯、直/间接眼底镜检查,同时行眼底彩色照相和德
2、国海德堡共焦激光视网膜仪(HRA102)的同步FFA和ICGA检查。结果:多灶性视网膜色素上皮(RPE)渗漏和脉络膜血管循环障碍(包括脉络膜血管充盈延迟以及脉络膜血管的扩张渗漏)是活动期MPPE患者在FFA和ICGA检查中的主要特征性改变。由于长期大量的RPE渗漏,部分患者会继发渗出性视网膜脱离,其中小部分在FFA检查中还有视网膜小血管普遍渗漏、视网膜无灌注区及新生血管形成、晚期视盘强荧光着色等慢性葡萄膜炎的改变。静止期MPPE患者在FFA和ICGA中的荧光改变则主要为RPE和脉络膜毛细血管的萎缩,而脉络膜血管充盈迟缓和血管扩张等循环异常变化基本消失。结论:MPPE有类似CSC的FFA和IC
3、GA改变,但程度更重;其中部分患者还可伴有类似慢性葡萄膜炎的改变。MPPE的ICGA后期像中的暗黑色低红外荧光灶有助于我们判断患者病情的预后。【关键词】脉络膜视网膜炎;色素上皮;吲哚青绿;诊断应用;荧光素血管造影术 Abstract AIM:Toobservethefeaturesandtheclinicalsignificanceoffundusfluoresceinangiography(FFA)andindocyaninegreenangiography(ICGA)inmultifocalposteriorpigmentepitheliopathy(MPPE).METHODS:Thec
4、linicaldataof35cases(51eyes)withMPPEduringJan.2007toApr.2009wereanalyzedretrospectively.Allthepatientsreceivedtheconventionalexamination,includingthevision,slitlamp,thedirect/indirectophthalmoscopeexamination,andthefunduscolorphotography,FFAandICGAwithheidelbergretinalconfocallaserinstrument(HRA2)
5、werealsocarriedout.RESULTS:Themultifocalretinalpigmentepithelial(RPE)leakageandchoroidalcirculatorydisturbances(includingchoroidalvascularfillingdelayaswellastheexpansion/leakageofchoroidalbloodvessels)werethemainfeaturesoftheMPPEinactivephaseexaminedbyFFAandICGA.Somepatientsoccuredtheexudativeretin
6、aldetachmentforalargenumberofRPEleakageandalongtimeleakage,inwhichsomechangessimilartochronic10uveitisappearedinasmallpartofpatientsincludingtheleakagesofretinalvessels,retinalnonperfusionareasandneovascularization,thediscwithstrongfluorescenceintheFFAlaterphase.ThechiefchangesweretheRPEandchorioca
7、pillarisatrophyinFFAandICGAwiththeMPPEinquiescentphase,butthechoroidalcirculationanomaliesdisappearedincludingthechoroidalfillingdelayanddilated.CONCLUSION:TheMPPEpatientshavesimilarchangeswithcentral
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