四妙合萆薢渗湿汤对急性痛风性关节炎的il1β、pge2的影响的实验研究

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1、四妙合萆薢渗湿汤对急性痛风性关节炎的IL1β、PGE2的影响的实验研究作者：叶红芳黄平应华忠寿旗扬【摘要】[目的]对四妙合萆薢渗湿汤治疗实验性大鼠急性痛风性关节炎的作用进行实验研究。[方法]采用向大鼠踝关节腔注射尿酸钠溶液建立急性痛风性关节炎模型，将四妙合萆薢渗湿汤用于模型的治疗，并与秋水仙碱做组间对照，观察其对关节肿胀度、关节局部IL1β、PGE2的含量的影响。[结果]1.大鼠踝关节肿胀度：造模后4h，高剂量中药组、中剂量中药组肿胀程度均降低(P<0.05);造模后12h，高剂量中药组、中剂量中药组肿胀程度均显著降低(P<0.01)，低剂量中药组有差异(P<0.05

2、);造模后24h，高剂量中药组、中剂量中药组均有显著差异(P<0.01);造模后48h，高剂量中药组有差异(P<0.05)，中剂量中药组有差异(P<0.05);2.IL1β：高剂量中药组关节局部IL1β下降(P<0.05);3.PGE2：高剂量中药组关节局部PGE2下降(P<0.05)。[结论]四妙合萆薢渗湿汤能减轻尿酸钠结晶所致急性痛风性关节炎关节肿胀度，能降低关节局部IL1β、PGE2水平。【关键词】四妙合萆薢渗湿汤;痛风;关节炎　　Abstract：[Objective]Toconfirmtheroleofsimiao9bixiedecoction

3、fordyingdampnessinthetreatmentofexperimentalacutegoutyarthritis.[Methods]Usethetreatmentofsimiaobixiedecoctionfordyingdampnesstothemodelestablishedbyinjectingmonosodiumurate(MSU)solutionintoanklecavitiesoftherats，andcomparewithcolchicine，toobservetheeffectofjointswellingdegree，theIL1βandPGE2conte

4、ntsoftheswellingjoint.[Results]1st：Ratsankleswellingdegree：Afterratsmodelsofacutegoutyarthritisestablished，highdoseandmediumdoseofChinesetraditionalmedicinecanreducethedegreeofankleswellingin4h(P<0.05).HighdoseandmediumdoseoftraditionalChinesemedicinecansignificantlyreducethedegreeofankleswelli

5、ngin12h.(P<0.01)，andlowdosegroupoftraditionalChinesemedicinehasdifferencecomparedwithmodelgroup(P<0.05).After24hours，highdosegroupandmediumdosegroupoftraditionalChinesemedicinebothhavesignificantdifferencebyprincipleofstatistics(P<0.01).After48hours，highdosegroupandmediumdosegroupoftradit

6、ionalChinesemedicinehavedifferencebyprincipleofstatistics(P<0.05).2nd：IL1βcontents：HighdoseoftraditionalChinesemedicinecanreducetheIL1βcontentsinswellingjoints(P<0.05).3rd：PGE2contents：HighdoseoftraditionalChinese9medicinecanreducethePGE2contentsinswellingjoints(P<0.05).[Conclusion]Simi

7、aobixiedecoctionfordyingdampnesscanreducethedegreeofankleswelling，reducethecontentsofIL1βandPGE2ofacutegoutyarthritisratsmodelsestablishedbyMSU.　　Keywords:Simiaobixiedecoctionfordyingdampness;gouty;arthritis　痛风是