冠心病患者血清e-选择素和ox-ldl的测定及意义

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1、冠心病患者血清E-选择素和Ox-LDL的测定及意义【摘要】目的：测定血清可溶性E-选择素、氧化性低密度脂蛋白(Ox-LDL)浓度在冠心病患者以及健康人中的变化，探讨血清可溶性E-选择素、Ox-LDL浓度在冠心病患者中的意义以及二者之间在冠心病的发生、发展过程中的关系。方法：选择90例冠心病患者，将其分为急性心肌梗死组（AMI组）、不稳定性心绞痛组（UAP组）、稳定性心绞痛组（SAP组）各30例，正常对照组30例，采用酶联免疫吸附法检测各组血清可溶性E-选择素、Ox-LDL水平，用t检验比较各组间的差异，用直线相关分析二者之间是否具有相关性。结果

2、：外周血中E-选择素和Ox-LDL的浓度在AMI组(67.84±11.08)μg/mL、(0.87±0.15)mg/L，UAP组(63.14±12.51)μg/mL、(0.78±0.16)mg/mL，SAP组(48.57±12.91)μg/mL、(0.65±0.22)mg/L，对照组(35.72±14.65)μg/mL、(0.51±0.21)mg/L；外周血中E-选择素和Ox-LDL的浓度在AMI组、UAP组、SAP组显著高于对照组（P<0.01）,外周血中E-选择素和Ox-LDL的浓度在AMI组、UAP组显著高于SAP组（P<0.

3、01）,冠心病患者外周血中E-选择素与Ox-LDL具有明显相关性。结论：冠心病患者血清可溶性E-选择素水平和Ox-LDL水平可反映病情严重程度，对病情的发展具有预见性，可作为冠心病患者的辅助诊断手段。【关键词】冠状动脉疾病；E-选择素；氧化性低密度脂蛋白10AbstractObjictive:ToevaluatetheroleofsolubleE-selectinandOx-LDLindifferentcoronaryheartdiseaseandthenormalandtoinvestigatetherelationshipoftheboth

4、withthedevelopmentofcoronaryheartdisease.Methods:90casesofcoronaryheartdiseaseweredividedintotheacutemyocardialinfarctiongroup(30cases),theunstableanginagroup(30cases)andstableanginagroup(30cases),with30normalcontrols.SerumlevelofsolubeE-selectinandOx-LDLwasmeasuredbyenzyme-

5、linkedimmunosorbentassay.ThedifferencesinsolubleE-selectinlevelandOx-LDLlevelbetweendifferentgroupswereobserved.PearsoncorrelationanalysistestwasusedtoanalyzetherelationshipbetweenthelevelofsolubleE-selectinandthelevelofOx-LDL.Results:ThelevelsofsolubleE-selectinandOx-LDLwer

6、eelevatedinAMI,UAPandSAPgroupsascomparedwiththecontrolgroup(P<0.01).ComparedwithSAPgroup,thelevelofsolubleE-selectinandOx-LDLwereelevatedinAMIandUAPgroups(P<0.01),whilethereisnosignificantdifferencebetweenAMIandUAPgroups.ThelevelsofsolubleE-selectinwerecorrelatedwithth

7、elevelsofOx-LDLindifferentcoronaryheartdisease.Conclusion:TheseriousdegreeofcoronaryheartdiseasewillbepredictedbythelevelsofsolubleE-selectin10andOx-LDLinserum.Thedevelopmentofcoronaryheartdiseasecanbeforeseen.ThelevelsofsolubleE-selectinandthelevelsofOx-LDLinserumcanactasaa

8、ssistantmethodforthediagnosisofcoronaryheartdisease.KeywordsCoronaryarteryd