c反应蛋白与血压和tcd参数的相关性

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1、C反应蛋白与血压和TCD参数的相关性作者：王小林　张明军王永红【摘要】目的了解C反应蛋白(CRP)与血压和TCD之间的关系。方法从2008年体检人群中选取1286名调查对象，按CRP值将调查对象分为低危组(CRP<3mg/L)936例，中危组(CRP3～10mg/L)240例和高危组(CRP>10mg/L)110例;分析各组年龄和TCD各指标的差异，比较不同组别高血压患者的构成比例，采用多因素Logistic回归分析高血压患者构成比例与不同CRP水平之间的相关性。结果与低危组比较，高危组和中危组左侧大脑中动脉和基底动脉的平均流速、舒张期流速明显降低(P

2、<0.05)，双侧大脑中动脉和基底动脉搏动指数、阻力指数有明显差异(P<0.05)，患病年龄也明显增大(P<0.05)。高危组(62.73%)和中危组(50.83%)患高血压的比例比低危组(37.82%)增加明显，患高血压的危险度分别是低危组的4.450倍(95%CI:2.967～6.674)和2.734倍(95%CI:2.064～3.621)。结论高水平的CRP能降低大脑中动脉和基底动脉血管弹性，诱导其动脉硬化的发生。同时，人群中患高血压的患者和风险也随之增加。【关键词】C反应蛋白;动脉硬化;高血压;TCD　　【Abstract】Objectiv

3、eToinvestigatetheassociationamongCreactiveprotein(CRP)andbloodpressureandthe11parametersoftranscranialdoppler(TD).MethodsThedatawascollectedfromsubjects(n=1286)forannualphysicalevaluationsof2008inthePublicHealthCenteroftheFirstAffiliatedHospitalofChongqingMedicalUniversityinChongqing.T

4、hedataswererandomizedbymultistepclustersamplingmethods.SubjectsweredividedintothreegroupsaccordinglevelsofCRP：(1)lowriskgroup：allsubjects’(n=936)levelsofCRPwerebelow3mg/L(2)midrangeriskgroup：allsubjects’(n=240)levelsofCRPwerebetween3mg/Land10mg/L;(3)highriskgroup：allsubjects’(n=110)

5、levelsofCRPweremorethan3mg/L.ThevariablesonsubjectsselectedforthisstudywereparametersofTD,theageofeachgroup,proportionateofhypertensionandtheassociationbetweenhypertensionandlevesofCRPwereanalyzed.ResultsThemeanglowvelocity,relaxingperiodvelocity,pulsatilityindexandresistentindexweresig

6、nificantlylowerinhighriskgroupandmidrangeriskgroup(P<0.05.vslowriskgroup);theageofthosegroupswasobviouslyoldercomparedwiththoseinlowriskgroup.Theproportionsofhypertensionweresignificantlyhigherinhighriskgroup(62.73%)andmidrangeriskgroup(50.83%)comparedtolowriskgroup(37.82%).Th

7、eprobabilitiesofhypertensioninhighriskgroup(OR=4.450CI:2.967～6.674)andmidrangerisk11group(OR=2.734CI:2.064～3.621)werehigherthanthatoflowriskgroup.ConclusionsHighlevelofCRPcancutdowntheelasticityofmiddlecerebralarteryandbasilarartery,inducetheappearanceofarteriosclerosisinbot