茶多酚乳剂促进皮肤溃疡愈合的实验研究

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1、茶多酚乳剂促进皮肤溃疡愈合的实验研究隋丽华1，郭珉1，李传勋2，杨彤2*，韩国柱2,李楠3（1.大连市皮肤病医院药剂科，辽宁大连，116021;2.大连医科大学药学院，辽宁大连，116044；*通讯作者;3.大连理工大学分析化学教研室,辽宁大连，116000）[摘要]目的：观察茶多酚乳剂促进家兔皮肤溃疡愈合的作用。方法：将15只白色家兔均分为5组，每组3只家兔。第1组为基质组（阴性对照），第2组为重组人表皮细胞生长因子组（阳性对照），第3、第4和第5组分别为茶多酚乳剂1％、3％和6％浓度组（小、中、大剂量组）。以涂搽药物后不同时间的各组溃疡面积，溃疡容积和

2、组织病理学检查为指标，观察茶多酚乳剂涂搽对溃疡愈合的影响。结果：涂搽茶多酚乳剂3天后，可使溃疡面积和容积缩小速度高于基质对照组。涂搽14天后，组织病理学检查显示6％的茶多酚乳剂组（大剂量组）表皮完全覆盖率和＞50%覆盖率高于基质对照组。结论：茶多酚乳剂涂搽皮肤溃疡面，可促进溃疡愈合。[关键词]茶多酚；乳剂；重组人表皮生长因子；皮肤溃疡；动物模型ExperimentalStudyoftheTeaPolyphenolCreamEnhancingHealingofSkinUlcerinRabbitShuiLihua1,GuoMin1,LiChuanxun2,Ya

3、ngTong2*,HanGuozhu2,LiNan3(1Departmentofpharmacy,DalianHospitalofDermatology,LiaoningDalian,116021;2Collegeofpharmacy,DalianMedicalUniversity,LiaoningDalian,116044;3DepartmentofAnalytic-Chemical,DalianUniversityofSciences,LiaoningDalian,116000.)[Abstract]Objective:Toinvestigatethe

4、effectsofteapolyphenolcream(TPC)enhancinghealingofskinulcersinrabbits.Methods:15albinorabbitswereusedinthisstudy.Fourskinulcerswiththesamedepthintohypodermawereincisedonthebackofeachrabbits.60ulcerweredividedintofivegroups:thefirstgroupweretreatedwithcreambase,thesecondgroupweretr

5、eatedwithrecombinanthumanepidermalgrowthfactor(rhEGF),thethirdgroup,thefourthgroupandthefifthgroupweretreatedrespectivelywiththeTPCofsmall,moderateandlargedoses.Theeffectonulcerhealingwasassessedbymeasurementsofulcerarea,ulcervolumeandhistopathalogicalchangesofeachgroup.Results:At

6、the3rddayafterTPCsmear,intheTPC-treatedgroupsandrhEGF-treatedgroup,ulcerareaandulcervolumeweresmallersignificantlytheninthecreambasegroup.Atthe14thdayafterTPCsmear,Histopathologicalexaminationrevealedthattherateofallulcerre-epithelializationandtherateofmorethanfiftypercentulcerre-

7、epithelializationinthe6%TPCgroupwerehigherthanthatincreambasegroup.Conclusion:Localapplicationoftheteapolyphenolcreamcanpromoteskinulcerhealing.[Keywords]teapolyphenol(TP);cream;recombinanthumanepidermalgrowthfactor(rhEGF);skinulcer;animalmodel.慢性皮肤溃疡（chronicskinulcer,CSU）是临床较常见的疾

8、病，常见于麻风病和糖尿病等患者。该病往往久治不愈，因此，称之为难治