smoflipid smofkabiven project - fresenius kabi：smoflipid smofkabiven项目费森尤斯卡比

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1、SMOFlipid:MorethanEnergyinaTPNA.Mallol.EAMARegion-07/08-30%-30%-25%-15%+200mg/lα-tocopherolWhatisit?SMOFlipidA.Mallol.EAMARegion-07/08SMOFlipidisaLEthatprovides…Immunomodulatoryandanti-inflammatoryeffects(EPA&DHA)FishOilLessperoxidativelongchainFAOliveoilAntioxidativeprotectionVitaminEA

2、rapidlyavailableenergysourcewithControlledTGserumLevelsMCTReliablesourceofEssentialFattyAcidsSoyaOilA.Mallol.EAMARegion-07/08SMOFlipidisaLEthat…VitEControlstheSerumLevelsofTGProtectstheLiverFunctionHaspositiveEffectsonImmunoresponseImprovesAntioxidantStatusAndReducesLOSinhospitalA.Mallol

3、.EAMARegion-07/08SMOFlipidClinicalEvidenceA.Mallol.EAMARegion-07/08ControlsserumLevelsofTGPatientsTreatedwithSMOFlipidpresentedcontrolledtriglyceridelevelswithatendencytolowerincreaseAdults:Antebi,2004;Genton,2004;Mertes,2006Children:Tomsits,2007;Goulet,2007;Rayyan,2007A.Mallol.EAMARegion-

4、07/08TheevolutionoftheplasmatriglycerideswassimilarinbothpatientgroupsA.Mallol.EAMARegion-07/08LowertriglycerideincreasedwasobservedintheSMOFlipidgroupfromday0(beforestartwithinfusion)today6(afterendofinfusionover5days)A.Mallol.EAMARegion-07/08ClinNutr,2004;23:793(abstract)MeanDurationTPNI

5、ntralipid20%12.3±1.8daysSMOFlipid10.9±2daysTheevolutionoftheplasmatriglycerideswassimilarinbothpatientgroupsA.Mallol.EAMARegion-07/08TheevolutionoftheplasmatriglycerideswassimilarinbothpatientgroupsA.Mallol.EAMARegion-07/08Nosignificantchangesinplasmatriglycerides,totalcholesterolorLDL-cho

6、lesterolinthetreatmentorthecontrolgroupA.Mallol.EAMARegion-07/08ProtectstheLiverFunctionBeneficialEffectswereobservedinliverfunctionofpatientstreatedwithSMOFlipidAdults:Antebi,2004;Mertes,2006Children:Tomsits,2007;Goulet,2007A.Mallol.EAMARegion-07/08Alanineaminotransferaseactivityafter5day

7、sofTPNwaslessincreasedintheSMOFlipidgroupA.Mallol.EAMARegion-07/08γ-GTlevelsincreasedduringTPNinbothgroups.TheriseintheSMOFlipidgroupwaslessmarkedthaninthesoybeanoilgroupA.Mallol.EAMARegion-07/08A.Mallol.EAMARegion-07/08OnlytheγGTwasobservedtobeincreasedinthes