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1、人类白细胞抗原D族与子痫前期-子痫相关性研究的系统评价中国循证医学杂志2006年第6卷第2期人类白细胞抗原D族与子痫前期/子痫相关性研究的系统评价林莉熊庆¨李幼平肖兵1.四川省妇幼保健院(成都610031);2.四川大学华西医院中国循证医学中心(成都610041)117【摘要l目的通过对子痫前期/子痫(PD'E)的观察性研究的系统评价研究人类白细胞抗原(HLA-DRs)与PE/E发病的相关性.方法采用自由词和主题词组配,计算机检索MEDLINE,EMBASE,Cochrane图书馆和CB—Mdisc,检索时间均截至2005年7月.对纳人研究进行质量评价,数据提取,并进行资
2、料分析.结果与对照组相比病例组母胎之问HLAIDR4抗原频率,OR值2.60,95%CI为(1.87,3.60),其差异具有统计学意义.与对照组相比病例组母胎间其他亚型的HLA-DR抗原频率差异均无统计学意义.病例一对照组夫妻间HLA—DR抗原频率相比,差异无统计学意义.病例一对照组夫妻间和母胎间HLA-DR共享差异均无统计学意义.结论总体而青,夫妻间HLAIDR.s抗原频率可能与PE/E发病无相关性;胎儿基因型别对PD'E可能有关.夫妻及母胎间HLA—DRs共享可能与PE/E无关.【关键词】子痫前期/子痫;人类白细胞抗原D族;系统评价AssociationofHuman
3、LeukocyteAntigen?DRsWithPre?eclampsia/Eclampsia:ASystematicReviewL/NLi
4、.)(1ONGQing.LIYou.ping2.XIAO8.n
5、.1.SichunProvincialHospitalforWomenandChildren,Chengdu610031,China;2.ChineseEvidence—BasedMedicineCentre,Chengdu610041,China.【Abstract】ObjectiveToinvestigatetherelationofHumanLeukocyteAn
6、tigen-DRstOPre-eclampsia/eclampsia(PE/E)byreviewingtheobservationalstudiesonPE/E.MethodsWesearchedtheMEDLINE/PubMed,EMBASE,TheCoehraneLibraryandCBMdisctOJuly2005,bycombiningfreetextwithMeSHwords.Weassessedthequali~ofincludedstudies,extractedandanalyzeddata.ResultsTheoddsratiooffetal—mater
7、nalHLA-DR4antigenfrequencyincasegroupversuscontrolgroupwas2.60(95%CI1,87tO3.60)withstatisticalsignificance.Theantigenfrequenciesofotherfetal-maternalHLA-DRsincaseandcontrolgroupswerenotstatisticallysignificant.TheantigenfrequenciesofthecoupleHLADRswerenotstatisticallysignificantbetweencas
8、eandcontrolgroups.WefoundthatneithertheHLA-DRsharingbetweenthecouplesnorbetweenfetusandmothersincaseandcontrolgroupswerestatisticallysignificant.ConclusionsTheantigenfrequenciesofHLA-DR.sbetweenthecouplesmayhavenoassociationwiththedevelopmentofPE/E.Thefe—talgenetypesmayberelatedtOthedevel
9、opmentofPE/E.TheHLA-DRsharinginmothersandfetusandthecouplesmayhavenoassociationwiththedevelopmentofPE/E.【Keywords】Pre-eclampsia/eclampsia;HLA-DRantigens;Systematicreview妊娠期高血压疾病(HDP)是妊娠期妇女的主要疾病,2000年其死亡居年我国孕产妇死亡第2位….我国妊高征协作组调查研究发现,HDP平均患病率占妇女的9.2%,其中子痫前期和子痫的患病率分别为1.
