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ID:13882527
大小:7.91 MB
页数:105页
时间:2018-07-24
《structural genomics of conserved gene families - rutgers…》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、StructuralgenomicsofconservedgenefamiliesByRamManiAdvisor:GaetanoT.Montelione,Ph.D.CenterforAdvancedBiotechnologyandMedicine;DepartmentofMolecularBiology&Biochemistry,Rutgers,TheStateUniversityofNewJersey--Piscataway,NJInfulfillmentofrequirementsfortheH
2、enryRutgersScholarsProgramMay2000AcknowledgementsIhavebeenworkinginDr.GaetanoMontelione'slaboratorysinceMay1997,whichmakesthenumberofpersonstothankverylarge.Ifsomeoneisexcludedpleaseforgiveme.MembersofDr.Montelione'slabhavebeentremendouslysupportive.Ron
3、gXiaohastaughtmesomuchduringmyproteinexpressionandpurificationwork.DaphnePalacioshasbeenanexcellentteacherduringmuchofthemolecularbiologyworkofmyCOGproject.Dr.KristinGunsalusprovidedessentialcoordinationduringmyworkwithCOG's,andherproteinexpressionkitha
4、sbeenavaluableresource.Severalothers(e.g.Drs.AlbertChienandParagSahasrabudhe)werealwayswillingtoanswermyquestionsaboutDNAandproteinpreparation.WithouttheworkofAlexandraGardinoandCharlesLu,myworkonCOG0229Swouldnothavebeenpossible.EmilyLywaskindenoughtosh
5、areinmymolecularbiologyworkinCOG0316S.GurmukhSahotahasbeenverygraciousinhelpingmeintimesofneed.Dr.MontelioneandDr.StephenAndersonhavebeenkindenoughtoserveonmythesispresentationcommitteeanddealwithdelaysthatcamewiththecompositionofthisthesis.Bothhaveprov
6、idedvaluableassistanceduringmycomputationalwork.Last,butnotleast,IwouldliketorecognizetheoveralldirectionthatDr.Montelionehasprovidedmeduringallofmyprojects.Hisintelligenceandcreativityandbeenlargemotivatingfactorsformywork.TableofContentsChapter1Introd
7、uctionPage1ExperimentalMethodsComputationalBiology5MolecularBiology10Biochemistry20ResultsandDiscussion30ConclusionandFutureWork41References43Legends45FiguresandTablesunpaginatedChapter2Abstract53Introduction54ExperimentalMethods55ResultsandDiscussion59
8、References66Table70FigureLegends75FiguresunpaginatedPrefacetothethesisThisthesiswaswrittenastwochapters,eachwrittenindependentlyoftheother.ChapteronedescribesworkthatIhavedoneduringinvestigationofthreedomainfamiliesofunknownfunct
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