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《金匮肾气丸论文：金匮肾气丸对2型糖尿病大鼠睾酮、性激素结合球蛋白及一氧化氮的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、金匮肾气丸论文：金匮肾气丸对2型糖尿病大鼠睾酮、性激素结合球蛋白及一氧化氮的影响【中文摘要】以传统中医学理论为指导,通过动物实验研究,观察金匮肾气丸对雄性2型糖尿病大鼠的雄激素水平和性功能的影响,并探讨其作用机理。方法：雄性SD大鼠40只,随机分成4组：正常对照组、模型组、阳性对照组、金匮肾气丸组,采用腹腔注射STZ的方式造模,正常对照组及模型组每日给予生理盐水灌胃,阳性对照组每日给予二甲双胍及万艾可灌胃,金匮肾气丸组每日给予二甲双胍及金匮肾气丸灌胃,连续给药4周,于末次给药12h后空腹测血糖、血脂、睾酮(T)、性激素结合球蛋白(SHBG)、一氧化氮(NO)。结果：金匮肾气丸组
2、及阳性对照组血糖均明显低于模型组(P<0.01),与正常组无显著差异性；金匮肾气丸组及阳性对照组T及NO均明显高于模型组(P(0.05),两组之间没有区别；阳性对照组SHBG明显高于正常组(P<0.05),而金匮肾气丸组与正常组无显著差异性；阳性对照组治疗后甘油三酯水平明显下降(P<0.05),与正常组无显著差异性；治疗后各组胆固醇均无显著差异性。结论：2型糖尿病可导致雄性SD大鼠性激素水平下降,而金匮肾气丸能有效改善雄性2型糖尿病大鼠的雄激素水平和提高性功能,但对血脂无明显降低作用,表明金匮肾气丸长于行肾气而无明显化痰湿的作用。【英文摘要】Abstract:Guidedbyt
3、raditionalChinesemedicine(TCM)theory,usethewayofanimalexperimentalstudy,toobserveiftheJinkuiShenqi(金匮肾气)pillcanimprovetheandrogenlevelsandenhancesexualfunctionaontype2diabeticrats,andtoexploreitsmechanism.Methods:40SDmaleratsweredividedintofourgroupsrandomly:normalcontrolgroup、modelgroup、pos
4、itivecontrolgroup、JinkuiShenqipilltreatedgroup.TheratswereinjectedinabdominalcavitieswithstreptozotocintomakeType2diabetesmodel.Physiologicalsalinewasirrigatedintothestomachsoftheratsinthenormalcontrolgroupandmodelgroup,metforminandvigrawereirrigatedintothestomachsoftheratsinthepositivecontr
5、olgroup,metforminandJinkuiShenqipillwereirrigatedintothestomachsoftheratsintheJinkuiShenqipilltreatedgroup.Afterfourweeks,fastingbloodglucose、testosterone、nitricoxideweretested.Result:TheGLUofJinkuiShenqipilltreatedgroupandpositivecontrolgroupweresignificantlyhigherthanmodelgroup(P(0.01),and
6、hasnodifferencewithnormalcontrolgroup;thetestosteroneandnitricoxideofJinkuiShenqipilltreatedgroupandpositivecontrolgroupweresignificantlyhigherthanmodelgroup(P<0.05),andthereisnodifferencebetweenthetwogroups;theSHBGofpositivecontrolgroupwassignificantlyhigherthannormalcontrolgroup(P<0.05),an
7、dthereisnodifferencebetweentheJinkuiShenqipilltreatedgroupandnormalcontrolgroup;Triglycerideaftertreatmentofpositivecontrolgroupwasfallensignificantly(P<0.05),andthereisnodifferencebetweenthepositivecontrolgroupandnormalcontrolgroup;Thereisnodiffer
