52 energy balance for crystalliser：对结晶器52的能量平衡

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1、MScPharmaceuticalandChemicalProcessTechnology(DT275)PharmaceuticalProcessesModuleCPPT9001AprocessfortheproductionofaspirinEmiliaKliszewska30ContentsPage1.0Abstract32.0Introduction33.0Calculationsforannualmassbalance54.0BatchBalanceCalculationsforeachstream125.0EnergyBa

2、lanceCalculations125.1EnergyBalanceforreactor135.2CrystalliserEnergyBalance155.3CentrifugeEnergyBalance165.4WashEnergyBalance175.5DrierEnergyBalance175.6DistillationEnergyBalance186.0EnergyBalanceSummary207.0Analysisoftheassumptions218.0Bibliography23Appendix1:Flowshee

3、tofaspirinproductionAppendix2:CalculationsforannualmassbalanceAppendix3:Tabulatedmassbatchbalanceforeachstream301.0AbstractItisrequiredtoprepareaPFDflowsheetandcarryoutanannual,batchmassbalanceandheatbalanceforaprocesstomanufacture1millionkilogramsofaspirin(acetylsalic

4、ylicacid).Aspirincanbeproductbythereactionofsalicylicacidwithaceticanhydrideinthepresenceofsulphuricacid.Theproductsofthereactionare:aspirin(acetylsalicylicacid),aceticacidandunreactedaceticanhydrideandsulphuricacid.Theprocessisbasedonthereactionbetweensalicylicacidand

5、20%stoichiometricexcessofaceticanhydrideand10%byweightconcentratedsulphuricacid(basedonthemassofsalicylicacid).Themainreactiontakesplaceinglass-linedorstainless-steelbatchreactor,inwhichthetemperatureis90°C.Attheendofthereactionperiod(5hours)theliquidproductmixtureistr

6、ansferredtocrystalliserwhereitiscooledfrom90°Cto0°C.Theaspirincrystallizesfromtheaceticacid/aceticanhydridemotherliquor.Theresultingsuspensionistransferredtoafilterforremovalofaceticacidandsolvent.Afterwashingwithsolvent,theaspirincrystalsareslurriedandfilteredagain.Th

7、easpirincrystalsarethendriedandsenttosifting,granulationandtableting.Aceticacid,whichisformedasaby–product,isrecoveredforsale.[1][2]2.0IntroductionAspirinisoneofthesafestandleastexpensivepainrelieversonthemarketplace.Whileotherpainrelieverswerediscoveredandmanufactured

8、beforeaspirin,theyonlygainedacceptanceasover-the-counterdrugsinEuropeandtheUnitedStatesafteraspirin'ssuccessattheturn