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1、丙卡巴肼(pcb、pcz、甲基苄肼)（PropylKaba(PCB,PCZ,methylhydrazine)）CarbacholAgeneralnameforChinese:propylenecarbonatehydrazineEnglishgenericname:ProcarbazineOthernames:Benzylhydrazine,methylbenzylhydrazine,propafenone,PloKaba,isopropylhydrazine"Clinicalapplication"Itismainlyusedinthetreatmentofmali
2、gnantlymphoma.Ithasalsobeenusedinthetreatmentofmalignantmelanoma,multiplemyeloma,lungcancerandbraintumors.Pharmacology1.pharmacodynamicsisaderivativeofhydrazine,belongingtononspecificcellcycledrugs.Thedrugitselfhasnoantitumoreffect,effectofredcellandlivermicrosomalenzymesinvivogeneratio
3、nofazoprocarbazineoxidation,thelatterthroughtheendoftheN-methyltransmethylation,somebasemethylshift7,adeninetoguanine1ortRNA,alkylatingspecificDNAsynthesisand.TheinhibitionofDNA,RNAandproteininterference,theproliferationoftumorcells.Thisdrughasnocellcyclespecificity,butmainlypreventsSce
4、llsfromenteringtheG2phase.Inaddition,thedrugisalsoamonoamineoxidaseinhibitor.2.pharmacokinetics,theoralabsorptionoffastandcomplete,serumconcentrationpeaktimeof30-60minutes,afterabsorptionrapidlydistributedinalltissuesofthebody,thehighestconcentrationintheliverandkidney,easytopenetrateth
5、ebloodcerebrospinalfluidbarrier.Mostofthemetabolismintheliver,plasmahalf-lifeisabout7-10minutes.Mainlyexcretedfromurine(about24hoursoutof70%),onlyabout5%ofthedrugprototype,asmallfractionofcarbondioxideandmethanedischargedthroughtherespiratorytract."Precautions"1.contraindications(1)alle
6、rgictothisdrug(foreigndata).(2)pregnantwomen.2.(1)withbonemarrowdysfunction.(2)diabeticpatients.(3)patientswithhepaticandrenaldysfunction.(4)patientswithinfection.(5)patientswhohaveundergoneradiotherapyorchemotherapyrecently.(6)lactatingwomen.3.theeffectofdrugsonchildrencanbeexcessivene
7、urotoxicity,thedosageshouldbeindividualized,andunderstrictclinicalmonitoringofdrugdelivery.4.,theeffectofdrugsontheelderlycanbereduceddosage.5.theeffectofdrugsonpregnancy,teratogeniceffectofthisdrug,pregnantwomenbanned(especiallyinthefirstthreemonthsofpregnancy).Theriskofpregna
