不同频率电针对抑郁症模型大鼠行为学和β-内啡肽的差异性研究

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1、不同频率电针对抑郁症模型大鼠行为学和β-内啡肽的差异性研究不同频率电针对抑郁症模型大鼠行为学和β-内啡肽的差异性研究王欣君王玲玲51015南京中医药大学第二临床医学院南京210038摘要[目的]观察不同频率电针对抑郁症模型大鼠行为学和β-内啡肽的差异[方法]制作慢性应激型抑郁症模型大鼠分别予以氟西汀假针2HZ电针100HZ电针治疗7天测定行为学表现和β-内啡肽水平[结果]2Hz电针组和100Hz电针组与模型组假针组氟西汀组比较糖水消耗量和水平运动垂直运动都有差异P＜005而氟西汀组与模型组假针组并无差异2HZ电针组和100HZ电针组比较糖水消耗量和水平运动无

2、差异但垂直运动有差异P＜0052Hz电针和100Hz电针脑内β-内啡肽β-EP水平均降低P＜0052Hz电针降低显著P＜0052Hz电针和100Hz电针β-EP水平均与糖水消耗量和水平运动有相关性但2Hz电针组在纹状体表现出相关性100Hz电针组在中缝核表现出相关性[结论]2Hz电针和100Hz电针对抑郁症模型大鼠均表现出抗抑郁快速起效特点2Hz电针效果优于100Hz电针该效应特点与β-EP水平降低有关2种频率电针β-EP水平与行为学的相关性表现在脑的不同部位β-EP的受体μ-受体及其信号通路的研究将是进一步深入研究的目标关键词针灸抑郁症频率β-内啡肽中图分类

3、号R395520TheDifferentInfluenceonBehavioralPerformanceandbeta-endorphinLevelsofDepressionModelRatsTreatedwithDifferentFrequenciesofElectro-acupunctureWANGXinjunWANGLingling253035402ndClinicMedicineSchoolNanjingUniversityofTCMNanJing210038Abstract[Objective]Toobservethebehavioralperfo

4、rmanceandbeta-endorphinlevelsofdepressionmodelratstreatedwithdifferentfrequenciesofelectro-acupuncture[Methods]wemadethechronicstress-induceddepressionmodelratswhichweretreatedwithfluoxetineshamacupuncture2HZEAand100HZEAforsevendaysrespectivelyandmeasuredthebehavioralperformanceandb

5、eta-endorphinlevelsofrats[Results]2HzEAgroupand100HzEAgroupbothincreasedinsugarconsumptionhorizontalmovementandverticalmovementcomparingwiththemodelgroupshamacupuncturegroupthefluoxetinegrouprespectivelyP005whiletherewasnodifferenceamongfluoxetinegroupmodelgroupandshamacupuncturegro

6、up2HZEAgroupcorrespondsto100HZEAgroupinsugarconsumptionandhorizontalmovementbut2HZEAhadanadvantageinverticalmotionP005β-endorphinbeta-EPdecreasedin2HzEAgroupand100HzEAgroupP005andsignificantlyin2HzEAgroupP0052HzEAand100HzEAwerebothrelatedtobeta-EPlevelsugarconsumptionandhorizontalmo

7、vementrespectivelybut2HzEAgroupshowsinthestriatumand100HzEAgroupintheraphenuclei[Conclusion]2HzEAand100HzEAbothshowantidepressantrapidonsetcharacteristicsondepressionmodelofratsand2HzEAismoreeffectivethan100HzEAThisisrelatedtothedecreasinglevelofbeta-EPThecorrespondencebetweenbeta-E

8、Pandbehaviorperform