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1、AnnAcadMedSingapore.2000Mar;29(2):246-8.AcasereportofAspergillushypersensitivitysyndromewithobstructingbronchialaspergillosis.LeeP,GohSK,YapWM,ChanCC.DepartmentofRespiratoryMedicine,TanTockSengHospital,Singapore.INTRODUCTION:A62-year-oldIndianmalewit
2、hdiabetesmellituspresentedwithatypical,overlapfeaturesofAspergillushypersensitivitysyndromeandobstructingbronchialaspergillosis.CLINICALPICTURE:Hewasfebrileandtachypnoeicwithdiffusecrepitationsandwheezing.ChestX-raywasnormalbuteosinophilcountwas2900/
3、mm3andIgE>10,000IU/ml.TREATMENTANDOUTCOME:Herespondedinitiallytohighdosesteroidtherapybutdeterioratedsubsequentlyfromextensivemucuspluggingofthebronchialtreewhichresultedinrespiratoryfailureanddeath.HewasHIV-negative.CONCLUSION:Cultureandhistologicex
4、aminationofbronchoscopicallyidentifiedtracheobronchialmucusplugsshouldbeperformedasearlytreatmentmaybelife-saving.PublicationTypes:·CaseReportsPMID:10895348[PubMed-indexedforMEDLINE]RevMalRespir.1990;7(6):609-12.RelatedArticles,Links[Endobronchialasp
5、ergillosisassociatedwithacarcinoidtumor][ArticleinFrench]QuoixE,GasserB,ApprillM,GourdonC,PauliG,RoegelE.PavillonLaennec,CHRUStrasbourg.Wereportacaseofa62yearoldmanwhopresentedwitheffortdyspnoeaaccompaniedbyacoughandhaemoptysis.Thechestradiographofth
6、ethoraxshowedatelectasisoftherightupperlobe.BronchoscopyshowedevidenceofatumourlikemassobstructingtherightbronchusandthisrevealeditselftobeamassoforganisedfibrinousdepositingranulationtissuecontainingnumerouscoloniesofAspergillus.Infactitappearedtobe
7、anobstructiveAspergillusbronchitis,withapseudo-tumourappearanceattachedtoacarcinoidtumourwhichwasobstructingtheapicalsegmentoftherightupperlobe.ObstructiveAspergillusbronchitismakesuponlyasmallpercentageofoverallrespiratorydiseasecausedbyAspergillus.
8、Theyposeaproblemofdifferentialdiagnosiswithbronchopulmonaryaspergillosiswhichismuchmorefrequent.PublicationTypes:·CaseReportsPMID:2270353[PubMed-indexedforMEDLINE]Am.J.Respir.Crit.CareMed.,Vol151,No.6,061995,2109-2115.Reviewoffungus-inducedasthmaticr
