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1、·1308·现代药物与临床Drugs&Clinic第29卷第11期2014年11月复方甘草酸苷注射剂致过敏性休克文献分析及预防措施1222222李红霞，张晋，刘冬，刘子昀，张晓钰，姜凤丽，乌伊萍1.宝鸡市中心医院药剂科，陕西宝鸡7210082.宝鸡市中心医院临床药学室，陕西宝鸡721008摘要：目的探讨复方甘草酸苷注射剂致过敏性休克的临床特点及规律，为合理用药提供参考。方法检索中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（维普）、万方数字化期刊全文库等数据库，对涉及病例的文献进行分析和讨论。结果复方甘草酸苷注射剂致
2、过敏性休克17例，其发生与患者年龄、性别无明显关系；其中15例（88.2%）发生在首次给药后的20min内，临床表现及解救方法与其他过敏性休克无明显差异。经积极的抗过敏性休克抢救，全部病例恢复正常，无死亡病例。医务人员对患者用药初期出现的不良反应不够重视是发生过敏性休克的安全隐患。结论复方甘草酸苷注射剂致过敏性休克并不罕见，医务人员应予以重视。关键词：复方甘草酸苷注射剂；过敏性休克；不良反应；文献分析中图分类号：R979.5文献标志码：A文章编号：1674-5515(2014)05-1308-07DOI:10.7501/j.
3、issn.1674-5515.2014.05.027DocumentanalysisandprecautionsonanaphylacticshockinducedbyCompoundGlycyrrhizinInjection1222222LIHong-xia,ZHANGJin,LIUDong,LIUZi-yun,ZHANGXiao-yu,JIANGFeng-li,WUYi-ping1.DepartmentofPharmacy,BaojiCentralHospital,Baoji721008,China2.Departmen
4、tofClinicalPharmacy,BaojiCentralHospital,Baoji721008,ChinaAbstract:ObjectiveToexploretheclinicalcharacteristicsandrulesofanaphylacticshockinducedbyCompoundGlycyrrhizinInjection,andtoprovidethereferencesfortherationaluseofdrugsinclinic.MethodsChinaJournalFull-textDa
5、tabase(CNKI),ChineseScienceandTechnologyJournalFull-textDatabase(VIP),WangfangDatabase,etcwereretrieved,andtheliteratureinvolvingcaseswereanalyzedanddiscussed.ResultsTherewere17anaphylacticshockcasescausedbyCompoundGlycyrrhizinInjection,andtheyhadnoobviousrelations
6、hipwithageandgender.Fifteencases(88.2%)occuredinthemedicationwithin20minafterivinfusion.Therewasnosignificantdifferenceinclinicalmanifestationsandrescuecomparedwithotheranaphylacticshock.Afteractiveanti-anaphylacticshockrescue,allpatientsreturnedtonormalwithnodeath
7、s.Itwasthesecurityrisktoanaphylacticshockthatmedicalstaffdidn’tpayattentiontoADRattheinitialtreatmentstage.ConclusionAnaphylacticshockinducedbyCompoundGlycyrrhizinInjectionisnotrare,andclinicalmedicalworkersshouldpayattentiontoit.Keywords:CompoundGlycyrrhizinInject
8、ion;anaphylacticshock;adversereaction;documentanalysis复方甘草酸苷是由甘草酸苷、甘氨酸及半胱氨酸苷最严重的不良反应，但发生率不明，而医务人酸组成的复合制剂，具有抗过敏、免疫调节、保护员往往对其未有足够的重视，为其用药安全埋下了肝细胞及抑
