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1、脐血铅、与初乳铅含量与新生儿神经行为发育关系刘康生作者单位:1安微医科大学公共卫生学院儿少妇幼系（合肥230032）2南京妇幼保健院检验科3南京妇幼保健院儿保科4南京妇幼保健院产科5南京儿童医院检验科210001作者简介：刘康生（1979-）,在读研究生,主管技师,从事微量元素和血铅儿保检验工作.通讯作者：郝加虎12郝加虎1顾平清2桂凌2时娟3戴春芳4徐飞51、安微医科大学公共卫生学院儿少妇幼系2、南京妇幼保健院检验科3、南京妇幼保健院儿保科4南京妇幼保健院产科5、南京儿童医院检验科[摘要]目的 探讨在宫内低水平铅暴露状态下,新生儿脐血铅含量及初乳铅铅
2、含量与神经行为发育的关系。方法 随机选取南京市妇幼保健院医院产科2010-01/04出生的足月新生儿170例。以脐血铅和初乳铅铅含量作为新生儿铅暴露的指标,新生儿神经行为（NBNA）发育评分作为效应指标。结果结果应以具体数据描述高暴露组在新生儿主动肌张力、原始反射,和神经行为发育总评分上低于低暴露组，差异有统计学意义(t=4.625，p<0.05),在新生儿行为能力、被动肌张力、一般估价上差异无统计学意义。结论初乳铅脐血铅水平和与婴儿的早期发育有关,铅可通过乳汁和脐血造成新生儿的铅接触,对新生儿婴儿早期神经行为发育产生不良影响。[关键词]新生儿;脐血铅
3、;乳铅;神经行为发育;早期指标.Relationshipofleadlevelsinumbilicalcordbloodandinforemilkwithneonatalneurobehavioraldevelopment。LIUkangsheng,HAOjiahu,GUpingqing.,GUIling,SHIjuan,XUfeietal.DepartmentofChildandAdoles-Schoolofpublichealth.ANHUImedicaluniversityhefei230032.Anhuiprovince.china.Depar
4、tmentoflaboratory.NanjingmaternityandchildHealthCarehospitalRelationshipBetweenLeadLevelsinUmbilicalCordBlood/ForemilkandNeonatalNeurobehavioralDevelopmentLIUKang-sheng,HAOJia-hu,GUPing-qing,etal.SchoolofPublicHealth,AnhuiMedicalUniversity,Hefei230032,AnhuiProvince,China.Departm
5、entofLaboratory.NanjingMaternityandChildHealthCareHospitalNanjing,210004,JiangsuProvince,China.[Abstract]:Objective:Toexploretherelationshipbetweenofleadlevelsinumbilicalcordbloodandinforemilkandthewiththeirneurobehavioraldevelop-mentofinneonateswithintrauterineexposuretoleadatl
6、owlevel.Methods:TotallyLevelsofleadinumbilicalcordbloodweredeter-minedfor170neonatesborninNanjingMaternityandChildHealthCareHospitalwererandomlyselectedtoevaluatetheirneurobehavioraldevelopmentaccordingtotheindicatorsofleadlevelsinumbilicalcordbloodandforemilk.ResultsThescoresof
7、initiativemuscletension,primitivereflexandneonatalneurobehavioraldevelopmentinhighexposuregroupwerelowerthanthoseinlowexposuregroup,thedifferenceswerestatisticalsignificant(t=4.625，p<0.05).Thedifferencesonneonatalbehaviorandpassivemuscletensionhadnostatisticalsignificance.Conclu
8、sionTheleadlevelsinumbilicalcordbloodandforemil
