雷诺昔酚对去势后大鼠骨密度、血生化指标的影响论文

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1、雷诺昔酚对去势后大鼠骨密度、血生化指标的影响论文【关键词】,卵巢切除术InfluenceofSERMraloxifeneonbonemineraldensityandbloodbiochemicalparametersinovariectomizedrats【Abstract】AIM:Tostudytheinfluenceofraloxifene(RAL),aselectiveestrogenreceptormodulator(SERM),onbonemineraldensity（BMD）lossincancellatedboneandp

2、actboneofovariectomizedrats.METHODS:TaleSDratsoperationgroup,ovariectomized（OVX）groupandtherapeutic（OVX+RAL）group.BilateralovariectomiesedinOVXgroupandOVX+RALgroup.ThelatteralfemoralsegmentandfemoralshafteasuredbydualenergyXrayabsorptiometry(DEXA).L2vertebraeorphometrical

3、lyanalyzedandserumbiochemicalmarkerseasuredbeforeandafterdrugadministration.RESULTS:Serumtotalcalcium［（3.02±0.38）mmol/Lvs（2.24±0.30）mmol/L］andtotalalkalinephosphatase［（2.336±0.032）μkat/Lvs（1.832±0.028）μkat/L］significantlyincreasedinOVXgroupparedgroup(P0.01,P0.05respective

4、ly).TheaboveparametersdecreasedinRALgroupparedizedgroup［（2.38±0.39）mmol/Lvs（3.02±0.38）mmol/L,（1.952±0.023）μkat/Lvs（2.336±0.032）μkat/L］(P0.05).Sixteeny,BMDofL3L5vertebrae,proximalfemoralsegment［（0.181±0.021）g/cm2vs（0.287±0.025）g/cm2］andfemoralshaft［（0.157±0.034）g/cm2vs（0.2

5、60±0.039）g/cm2］decreasedsignificantly(P0.01)andthetrabecularbecamethinandirregularparedgroup.AftertreatmentofRAL,theaboveparametersrestored(P0.05)butnottothelevelofshamgroup(P0.05).CONCLUSION:Ovariectomyinducesasignificantdecreaseofcancellatedbonemassandpactbonemass.RALis

6、aneffectivemedicinetoinhibitboneloss,increasetheBMDoflumbarspine,.freely；osteoporosis;selectiveestrogenreceptormodulator；raloxifene;metabolism;bonedensity【摘要】目的：研究选择性雌激素受体调节剂(SERM)雷诺昔酚（RAL）对去势后雌性大鼠血生化及骨密度(BMD)的影响.方法：将5mo龄未经产雌性二级SD大鼠24只，随机分为假手术(Sham)组、去势(OVX)组、去势＋RAL(OVX+R

7、AL)组.OVX+RAL组大鼠术后7d开始给药.术后16组相比较，血钙（Ca2+）明显增高［（3.02±0.38）mmol/Lvs（2.24±0.30）mmol/L,P0.01］，血碱性磷酸酶(ALP)升高［（2.336±0.032）μkat/Lvs(1.832±0.028)μkat/L,P0.05］，血磷(P)无明显差异.OVX+RAL治疗组与OVX组相比，血清Ca2＋.freelmol/Lvs(3.02±0.38)mmol/L,(1.952±0.023)μkat/Lvs(2.336±0.032)μkat/L,P0.05］，血P无明显差

8、异.与Sham组相比，OVX组股骨近端［（0.181±0.021）g/cm2vs(0.287±0.025)g/cm2］、股骨干［（0.157±0.034）g/cm2vs(0.260±0.039