资源描述：
《复发性多软骨炎22例临床研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、复发性多软骨炎22例临床研究[摘要]目的:提高对复发性多软骨炎的认识。方法:回顾性分析22例复发性多软骨炎患者的临床资料。结果:呼吸道受累15例(68%)、眼部受累15例(68%)、耳软骨炎14例(64%)、关节炎/关节痛共11例(50%)、鼻软骨炎10例(45%)、内耳受累9例(41%)、皮肤受累5例(23%)。实验室检查无特异性。呼吸道受累者喉镜检查可见声带水肿、喉管狭窄,支气管镜检查可见气管狭窄和软骨消失等表现。所有患者均接受糖皮质激素及免疫抑制剂治疗。10例呼吸道受累者自发病开始一直未完全缓解,其中3例接受气管
2、切开术,2例接受气管内支架治疗。结论:复发性多软骨炎临床表现多样,易误诊,呼吸道受累比例高且预后差,糖皮质激素联合免疫抑制剂治疗有效,有呼吸道狭窄及塌陷者需辅以手术或介入治疗。�[关键词]复发性多发性软骨炎;回顾性研究;临床表现;诊断;治疗�[中图分类号]R593.2;R453;R61[文献标识码]A[文章编号]1671-7562(2010)01-0053-04�doi:10.3969/j.issn.1671-7562.2010.01.015Clinicalanalysisof22patientswithrelapsi
3、ngpolychondritisGENGJie�1,YEShuang�2,BAOChun-de�214(1.DepartmentofRheumatology,JiangsuProvincialHospitalofIntegratedTraditionalandWesternMedicine,Nanjing210028,China;2.DepartmentofRheumatology,RenjiHospitalinShanghai,Shanghai200001,China)[Abstract]Objective:Toen
4、hancetheunderstandingofrelapsingpolychondritis(RP).Methods:Theclinicalmanifestations,diagnosis,andtreatmentof22patientswithRPwereretrospectivelyanalyzed.Results:Sitesinvolvedincludedairwayin15patients(68%),eyesin15(68%),earcartilagesin14(64%),jointsin11(50%),nas
5、alcartilagesin10(45%),andinnerearsin9(41%),skinin5(23%).Laboratoryexaminationhadnospecificity.Laryngoscopyrevealedvocalfoldedemaandlaryngealstenosis.Bronchoscopyshowedstenosisoftracheaandbothmainbronchianddestructionoftracheobronchialcartilage.Allpatientsreceive
6、dcorticosteroidsandimmunosuppressivedrugs.10patientswhoseconditionneverinprovedafterregulartherapyallhadairwayinvolvement.Amongofthem,3patients14receivedtracheotomyand2patientsreceivedmetallicstentsfortheirtracheobronchialstenosis.Conclusions:Theclinicalmanifest
7、ationinpatientswithRPisdiversityandtendestobemisdiagnosed.PrevalenceofairwayinvolvementisnotsolowwithapoorprognosisinpatientswithRP.CorticosteroidsandimmunosuppressivedrugsareeffectiveonRP.Patientswithlaryngotrachealstenosisandcollapsedtracheobronchialwallshould
8、receivelaryngostomy,tracheostomyorairwaystentingtoimproveairwayobstructionsymptoms.�[Keywords]relapsingpolychondritis;retrospectivestudies;clinicalmanifestation;diagn
