甘精胰岛素及诺及灵n分别及格列美脲联合治疗2型糖尿病疗效比较

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1、甘精胰岛素及诺及灵N分别及格列美脲联合治疗2型糖尿病疗效比较【摘要】目的比较甘精胰岛素和诺和灵N分别与格列美脲联用治疗2型糖尿病患者的疗效。方法选择40例口服降糖药治疗至少3个月而血糖控制不佳（HBA1c>7.0%）的2型糖尿病患者自选睡前注射一次甘精胰岛素或诺和灵N联用格列美脲2～4mg早晨一次口服治疗16周。比较甘精胰岛素组或诺和灵N组治疗前后FPG和HbA1c的变化并评估两组间的差异性。结果治疗16周时，甘精胰岛素组和诺和灵N组的HbA1c值分别下降1．9±0．8%和1．8±0．9%(P=0．686

2、4)，空腹血糖水平分别下降3．5±1．4mmol/L和3．1±1．5mmol/L(P=0．4373)，两组疗效间的差异均无统计学意义。甘精胰岛素组较诺和灵N组发生症状性低血糖人数(6/14vs14/6;P=0．0105)和发生夜间低血糖次数(6vs31;P=0．0040)都显著性减少。结论睡前注射一次甘精胰岛素或诺和灵N联用格列美脲2～4mg早晨口服的治疗方法可使单纯口服降糖药控制不佳的2型糖尿病患者得到良好的血糖控制。两种方法的疗效大致相同，但甘精胰岛素治疗低血糖事件发生率低,故更具选择优势。【关键词】

3、糖尿病，2型；甘精胰岛素;低血糖ComparisonofTherapeuticEffectsBetween9GlargineandNovolinNCombinedRespectivelywithGlimepirideinType2DiabetesMellitusHANChun-sheng,DepartmentofEndocrinology,ThirdAffiliatedHospitalofQiqihaerMedicalCollege,Qiqihaer,161000,China【Abstract】Objec

4、tiveTostudycomparisonoftherapeuticeffectsbetweenglargineandNovolinNcombinedrespectivelywithglimepirideintype2diabetesmellitus.MethodsFourtytwopatientswithtype2diabetesinplasmaglucosepoorlycontrolled（HBA1c>7.0%）withtreatmentoforalhypoglycemicagentsatleastt

5、hreemonths,freechoicebyoneself，injectedglargineorNovolinNbeforesleepcombinedwithtreatmentofglimepiride2~4mginthemorningonceeverydayfor16weeks.ThechangesofFPG和HbA1clevelsbeforeandafterthetreatmentwerecomparedbetweenglarginegroupandNovolinNgroup,anddifferen

6、cesbetweenthetwogroupswereevaluated.ResultsBy16weeks,themeanvalueofHbA1cinglarginegroupandNovolinNgroupdecreasedrespectively1．9±0．8%and1．8±0．9%(P=0．6864),themeanvalueofFPGdecreased9respectively3．5±1．4mmol/L和3．1±1．5mmol/(P=0．4373),therewerenosignificantdif

7、ferenceatefficacybetweenthetwogroups.Thenumbersofsymptomatichypoglycaemia(6/14vs14/6;P=0．0105)andincidenceofhypoglycemiaatnight(6vs31;P=0．0040)decreasedsignificantlyinglarginegroupcomparedwithNovolinNgroup.ConclusionThepresentstudyshowedthatpatientswithty

8、pe2diabetesinplasmaglucosepoorlycontrolledwithtreatmentoforalhypoglycemicagentscanbewellcontrolledbyinjectionofglargineorNovolinNbeforesleepcombinedwithtreatmentofglimepiride2~4mginthemorningonceeveryday.Theefficacy