近红外光谱技术在帕金森病大鼠脑组织射频毁损术中应用

《近红外光谱技术在帕金森病大鼠脑组织射频毁损术中应用》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、近红外光谱技术在帕金森病大鼠脑组织射频毁损术中应用［摘要］目的探索近红外光谱（NIRS）技术用于立体定向靶点毁损术中实时监测的可行性，并观察此过程中NIRS参数的变化规律。方法在大鼠脑纹状体采用两点注入法注入6-OHDA建立帕金森病（PD）大鼠模型；对正常及PD大鼠进行射频毁损，观察并记录脑组织靶点毁损时的NIRS尤其是优化散射系数的变化情况。结果（1）50只大鼠中有40只经阿扑吗啡(APO)诱导后表现为恒定左侧旋转，旋转圈数超过7r•min-1。（2）射频毁损丘脑腹外侧核（Vim）时，在各温度点下NIRS出现特征性变化曲线。�结论利用NI

2、RS实时活体在位监测帕金森大鼠射频神经核团毁损术是科学、可行的，优化散射系数是监测的良好指标。�［中图分类号］R742；R-33［文献标识码］A［文章编号］1671-7562（2008）04-0225-05�［关键词］近红外光谱技术；优化散射系数；立体定位技术；帕金森病；神经核团毁损术；大鼠Applicationofnear-infraredspectroscopytechnologyinstudyingthedamage�ofratswithParkinsondiseasebyradiofrequency�� 13WUQi�1，YANGTian-mi

3、ng�1，QIANZhi-yu�2，MAOWen-lan�2,GUOLi-na�2,HELiang�1（1.DepartmentofNeurosurgery,ZhongdaHospital,SoutheastUniversity,Nanjing210009,China；�2.DepartmentofBiomedicalEngineering,NanjingUniversityofAeronauticsandAstronautics,Nanjing210016,China）Abstract:ObjectiveToexplorethefeasibility

4、ofusingnear-infraredspectroscopy(NIRS)technologytomonitorreal-timetargetinthestereotacticdestructiontechnologyandtoobservetheprocessofchangesintheparameters.MethodsTheestablishmentofanimalmodels：inject6-hydroxydopamine(6-OHDA)intothestriatumattwopointstoestablishtheratmodelofPar

5、kinsondisease(PD).Targetdestructioninnearinfraredspectroscopymonitoring：reversibleradiofrequencyablationwasimplementedonnormalandPDrats.Changesinbraintissue,thechangesofreducedscatteringcoefficientinparticular,wereobservedandrecordedbybraintissuespectroscopy.Results13(1)Fourtyou

6、tof50ratsinducedbyAPOperformedconstantleftrotationwithrotarylapslargerthan7r•min-1.(2)Whenventrolateralthalamusnuclear(Vim)wasdestroyedbyradiofrequencyablation,nearinfraredspectraldisplayacharacteristiccurveunderdifferencetemperatures.ConclusionReal-timeuseofnearinfraredte

7、chnologyinvivotomonitorRFpowerindamagednucleusofratswithPDisscientificandfeasible.Inaddition,thereducedscatteringcoefficientisagoodindicatorformonitoring.�Keywords:near-infraredspectroscopy；reducedscatteringcoefficient；stereotactictechnology；Parkinsondisease；ablativeprocedure;ra

8、ts�(ModernMedicalJournal,2008,36:225-229)帕金森病（P