非小细胞肺癌患者外周血中muc1基因的定量表达及其临床意义-胸外科学专业论文

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1、优秀毕业论文非小细胞肺癌患者外周血中M001基因的定量表达及其临床意义摘要目的：探讨Mucin-1(MUCl)基因在t6,1,细胞肺癌(NSCLC)患者外周血中的表达及临床意义。方法：采用实时荧光定量RT—PCR法检NMUCJ基因在NSCLC患者外周血及正常人外周血的表达。结果：NSCLC患者外周血中，MUClmRNA表达显著高于『F常人外周血(t=2．0141，P=-I．5451E-13，P(O．05)；鳞癌与腺癌患者MUClmRNA的表达量无明显差别(t=2．0244，P=-O．5151，P>O．05)；MUClmRNA表达量与NSCLC的病理分级(F：25．6186，P=-3

2、．7329E-08，P

3、．精品参考文献资料优秀毕业论文QUANTlTATIVEEXPRESSIONANDCLINICALSIGNIFICANCEOFMUClmRNAINPERIPHERALBLooDOFPATIENTSWITHNON．SMALLCELLLUNGCANCERAbstractObjectiveTostudythequantitativeexpressionandclinicalsignificanceofMUC1mRNAinperipheralbloodofpatientswithnon—smallcelllungcancer(NSCLC)．MethodsReal—timefluorescen

4、tquantitativeRT—PCRmethodwasappliedtoinvestigatethequantitativeexpressionofMUC1mRNAinperipheralblood(PB)ofpatientswithNSCLCandhealthycontrols．ResultsThelevelsofMUC1mRNAexpressioninNSCLCweresingnificantlyhighel"thanthoseinhealthycontrols(t=2．0141，P=-I．5451E一13，P

5、A(t=2．0244．P=0．5151)wereofnodifferencebetweensquamouscarcinomaandadencarcinoma(P>0．05)：MUClmRNAwascorrelatedwithpathologicalgrades(F=25．6186，P=3．7329E-08，P

6、patientscorrelatedintimatelywithpathologicalgrade。lymphnodemetastasisandTNMstages．Lowerdifferentiation．1aterTNMstageandlymphnodemetastasisshowedhigherexpression，otherwise，theconditionwasonthecontrary．ConclusionsAbnormalexpressionofMUC1mRNAcorrelatesintimatelywiththeoccurance，development，infest

7、ation，metastasisandmalignancyofNSCLC．MUC1mRNAexpressioninPBmayactasanestimationofmalignancyandprognosisofNSCLC．Postgraduatestudent：XiangfengJin(ThoracicSurgery)DirectedbyProf．YiShenandVice-Prof．Yu-chengWeiKEYWORDS：MUCI；Non--SmallCellLun