401 2009 article 619外语英文电子书

401 2009 article 619外语英文电子书

ID:7886836

大小:1.20 MB

页数:29页

时间:2018-03-01

401 2009 article 619外语英文电子书_第1页
401 2009 article 619外语英文电子书_第2页
401 2009 article 619外语英文电子书_第3页
401 2009 article 619外语英文电子书_第4页
401 2009 article 619外语英文电子书_第5页
资源描述:

《401 2009 article 619外语英文电子书》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库

1、ActaNeuropathol(2010)119:7–35DOI10.1007/s00401-009-0619-8REVIEWAstrocytes:biologyandpathologyMichaelV.Sofroniew•HarryV.VintersReceived:17November2009/Revised:23November2009/Accepted:24November2009/Publishedonline:10December2009ÓTheAuthor(s)2009.Thisarticleispublis

2、hedwithopenaccessatSpringerlink.comAbstractAstrocytesarespecializedglialcellsthatout-Increasingevidencepointstowardsthepotentialofreactivenumberneuronsbyoverfivefold.Theycontiguouslytiletheastrogliosistoplayeitherprimaryorcontributingrolesinentirecentralnervoussyst

3、em(CNS)andexertmanyessen-CNSdisordersvialossofnormalastrocytefunctionsorgaintialcomplexfunctionsinthehealthyCNS.Astrocytesofabnormaleffects.Thisarticlereviews(1)astrocyterespondtoallformsofCNSinsultsthroughaprocessfunctionsinhealthyCNS,(2)mechanismsandfunctionsofr

4、eferredtoasreactiveastrogliosis,whichhasbecomeareactiveastrogliosisandglialscarformation,and(3)waysinpathologicalhallmarkofCNSstructurallesions.SubstantialwhichreactiveastrocytesmaycauseorcontributetospecificprogresshasbeenmaderecentlyindeterminingfunctionsCNSdisor

5、dersandlesions.andmechanismsofreactiveastrogliosisandinidentifyingrolesofastrocytesinCNSdisordersandpathologies.AvastKeywordsAstrocyteReactiveastrogliosisGlialscarmoleculararsenalatthedisposalofreactiveastrocytesisGFAPPathologyCentralnervoussystembeingdefined.

6、Transgenicmousemodelsaredissectingspecificaspectsofreactiveastrocytosisandglialscarformationinvivo.AstrocyteinvolvementinspecificIntroductionclinicopathologicalentitiesisbeingdefined.Itisnowclearthatreactiveastrogliosisisnotasimpleall-or-nonephe-Untilquiterecently,th

7、eprevailingviewregardingthebiol-nomenonbutisafinelygradatedcontinuumofchangesthatogyandpathologyofastrocytesamongthosestudyingoccurincontext-dependentmannersregulatedbyspecificclinicaldisordersandstructurallesionsofthecentralnervoussignalingevents.Thesechangesrangef

8、romreversiblesystem(CNS)wasmostlikelytobethat(1)astrocytesarealterationsingeneexpressionandcellhypertrophywithsupportiveglialcellcomponentsinneuraltissu

当前文档最多预览五页,下载文档查看全文

此文档下载收益归作者所有

当前文档最多预览五页,下载文档查看全文
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。