最新青霉素类药物的结构改造.教学讲义PPT课件.ppt

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1、青霉素类药物的结构改造.1.青霉素结构特征：由β-内酰胺环、氢化噻唑环及酰基侧链构成β-内酰胺环四氢噻唑环酰胺侧链一、青霉素类药物概述6-氨基青霉烷酸2.天然青霉素存在的不足：不耐酸，只能注射给药易产生耐药性抗菌谱窄，仅对革兰阳性菌有效有严重的过敏反应书信感谢信ALetterofThanksIwouldliketothankyoufromthebottomofmyheartfor…I’mwritingtoexpressmysinceregratitudefor…I’mgratefultoyouf

2、or…Itrulyappreciateyour…Wordsfailtoconveymygratitudetoyoufor…道歉信ALetterofApologyIwouldliketoexpressmyapologyfor…Pleaseacceptmysincerestanddeepestapologyfor…I’mterriblysorrytotellyouthat…Willyoudogoodenoughtoexcusemefor…I’mwritingtoapologizetoyoufor…W

3、ouldyoumindifIchangetheappointmenttime?Tomakeupmythoughtlessbehavior,I…（我想。。。以弥补）IwishIcouldbegivenachancetomakeupformyinconsideration.投诉信ALetterofComplaintMuchtomyregret,Iamwritingtomakeacomplaintabout/against…Iamcompletelydisappointed/upsettofind…I

4、amwritingtoinformyouofmyunhappyexperience.Iwouldliketodrawyourattentionto…Iwouldbeveryobligedifyoucouldlookintothismatterassoonaspossible.（若你能尽快调查此事，我讲不胜感激）Toimprovethesituation/solvetheaboveproblem,itisadvisableforyoutotakethefollowingmeasures.Iwoul

5、dliketoseeapromptsettlementoftheissue.Wewillappreciateyourwillingnesstomakeupfortheloss.（我们真的希望你们能对损失做出补偿）建议信ALetterofSuggestionIamwritingtoexpressmyviewsconcerning…Youhaveaskedmeformyadviceabout…,andIwilltrytomakesomeconstructivesuggestions.Iwouldli

6、ketosuggestthat…Iamwritingtoputupsomesuggestionsconcerning…It’smygreathonortorecommend…Thankyouforyourattention.申请信ALetterofApplicationIamwritingtoyouthislettertoshowmykeeninterestinthepostof…,whichyouadvertisedinyesterday’sChinaDaily.Inreplytoyourad

7、vertisementin…,Ibegtoapplyforthepostof…inyourcompany.Iwouldliketoapplyforthepositionof…Iwouldliketoapplyforthescholarshipthatyourschoolmaybeoffering.Iamverygladtoavailmyselfofthechancetorecommendmyselftoyou.Mynameis…I’mstudyingin…,majoringin…拒绝信ALett

8、erofRefusalManythanksforyourletterdated10thOctober,invitingmeto…ButIamsorrytotellyouthatIshallnot…because…IamterriblysorrytosaythatIamunableto…IammuchtouchedbyyourkindinvitationbutIdonotseeanychanceofmybeingabletobethere.询问信ALetterofInquiryI’mwriting