资源描述：
《第1-4章微流控芯片ppt课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、第1-4章微流控芯片目录发展背景制备技术流体控制典型实例商品简介目录发展背景制备技术流体控制典型实例商品简介Doyouknow?Biochip生物芯片Lab-on-a-Chip芯片实验室LabchipMicrofluidicChip微流控芯片MicroTotalAnalysisSystem(MicroTAS,TAS)微全分析系统Researchintominiaturizationisprimarilydrivenbytheneedtoreducecostsbyreducingtheconsumptionofexpensivereagentsand
2、byincreasingthroughputandautomation.Forexample,mostareawareoftheincreasingcostofhealthcare,driveninpartbythecostofimplementingthelatestdiagnosticassays.Theseassays,whichareusuallyperformedinmicrotiterplatesthatconsumehundredsofmicrolitersofreagents,wouldbenefitfromtheuseofmicro
3、fabricatedarraysofnanolitervolumevials.Byreducingreagentconsumptionbyafactorof103–104,thesedevicescouldprovidedramaticsavingsfortherepetitiveassaysoftenperformedindiagnosticlaboratories.Whyminiaturization？Anal.Chem.2000,72,330A-335AInthesamewaythatintegratedcircuitsallowedforth
4、eminiaturizationofcomputersfromthesizeofaroomtothesizeofanotebook,miniaturizationhasthepotentialtoshrinkaroomfullofinstrumentsintoacompactlab-on-a-chip.Anal.Chem.2000,72,330A-335A尺寸效应（cm→100m）尺寸1/100分子扩散时间1/10,000(1h→0.36s)体积1/1,000,000试剂用量1t→1g,ml→nl传热速度1500oC/s由此将带来：方法上的变革理论
5、上的突破还有巨大的经济和社会效益微流控分析芯片微流控分析芯片目的是通过化学分析设备的微型化与集成化，最大限度地把分析实验室的功能转移到便携的芯片中。微流控分析芯片通过微机电加工技术把整个实验室的功能，包括采样、稀释、加试剂、反应、分离、检测等集成在几平方厘米的微流控芯片上，且可多次使用，因而极大地减少了样品和分析试剂的用量，降低了分析的成本，加快了分析的速度，具有广泛的适用性。TheEarlyDays:1975-1989ThefirstanalyticalminiaturizeddeviceAgaschromatographicairanalyzer
6、fabricatedonasiliconwaferTerry,S.C.Ph.D.Thesis,Stanford,Stanford,CA,1975Terry,StephenC.;etal.IEEETransactionsonElectronDevices,1979,ED-26(12),1880Aminiaturegasanal.systembasedontheprinciplesofgaschromatog.ThemajorcomponentsarefabricatedinSiusingphotolithog.andchem.etchingtechni
7、ques,whichallowssizeredns.ofnearly3ordersofmagnitudecomparedtoconventionallaboratoryinstruments.consistsofasampleinjectionvalve,a1.5-m-longcapillarycolumn.Athermalconductivitydetectorfabricatedonaseparatesiliconwafer.sepns.ofgaseoushydrocarbonmixts.areperformedin<10s.发展历史Photog
8、raphofagaschromatographintegratedonaplanarsiliconwafer
