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1、Unite2TextAWords:mechanismofaction,selectivetoxicity(penicillinandsulfadrugs),chemotherapy,pharmacokinetics（absorption,distribution,metabolismandexcretion）,pharmacodynamics,structure-activityrelationship,Knowledgepoints:lmechanismsofactionofaspirinandpeni
2、cillinldrugtargetlclassificationofdrugs(exampleslistedineachcategory)TextBWords:adversedrugreactions,toxicreaction,sideeffect,secondaryeffect,idiosyncraticreaction,allergicreactionKnowledgepoints:lexampleslistedineachsubtypeofADRldifferencebetweentypeAand
3、typeBreactionslaetiologyofADR(particularlyenzymeorreceptorpolymorphism,genepolymorphism)lADRmonitoringinphaseI/II/III/IVclinicaltrialsUnite3TextAWords:oil-to-waterpartitioncoefficient,first-passeffect,dissolution,bioavailability,parenteraladministration,s
4、uspendingagent,emulsifyingagent,propellantKnowledgepoints:lsolutions:homogeneousmixturelinjectionslEffervescenttabletanditsadvantagelsublingualtabletanditsadvantagelentericcoatedtabletanditsadvantagelcomparisonbetweenhardandsoftcapsuleinthreeaspects:shell
5、s,production,drugslcomparisonamongsolutions,suspensionsandemulsionslcontinuousphaseanddispersedphaseinemulsions,oilinwaterandwaterinoilemulsionsltopicalandsystemiceffectandaerosolTextBWords：activeingredient,excipient,Knowledgepoints:lexcipientsinparentera
6、lformulationsandtheirfunctionsUnite5TextAWords:aminoacid,polypeptide,peptidebond,enzyme,activesite,proenzyme(zymogen),cofactor,isoenzyme,Knowledgepoints:lthreecharacteristicsofenzymelregulatoryprotein:insulin,repressortransportprotein:hemoglobin,serumalbu
7、min,membranetransportproteins(cailciumchannel)TextBWords:nucleotides,Knowledgepoints:ldifferencebetweenDNA,geneandchromosomeldifferencebetweenDNAandRNAltwostagesingeneexpression:transcriptionandtranslationlDNAdoublehelixlDNAreplicationlone-gene-oneenzymet
8、oone-gene-one-polypeptide:alkaponuiraandsicklecellanemia
