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时间:2020-05-20
《相关自身抗体在女性不孕患者中的检测意义.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·正·MedicalLaboratoryScienceandClinics,2011,Vo122,No.5医学检验与临床2011年第22卷第5期doi:10.3969/j.issn.i673—5013.2011.05.002相关自身抗体在女性不孕患者中的检测意义黄泽棋周少雄谢伟贤江志兰邓爱红沈永坚(佛山市第二人民医院检验科,广东佛山528000)【摘要】目的探讨女性不孕患者血清中不孕五项相关自身抗体在免疫性不孕症中的检测意义。方法采用酶联免疫吸附试验测定168例女性不孕患者血清中的抗精子抗体、抗HCG抗体、抗卵巢抗体、抗心磷脂抗体和抗子宫内膜
2、抗体,同时测定健康已育者66例作为对照组。结果在168例女性不孕患者中,血清抗精子抗体、抗HCG抗体、抗卵巢抗体、抗心磷脂抗体和抗子宫内膜抗体的阳性例数分别为29、3、6、2和5,阳性率分别为17.3%、1.8%、3.6%、1.2%和3.O%。在66例对照组中,上述抗体的阳性例敷分别为2、0、0、0和l,阳性率分别为3.【)%、0、0、0和1.5%。经卡方分析,不孕组抗精子抗体阳性率明显高于正常对照组(P<0.05)。不孕组抗HCG抗体、抗卵巢抗体、抗心磷脂抗体和抗子宫内膜抗体阳性率高于正常对照组,但是差异无统计学意叉(P>0.05)。结论抗
3、精予抗体是女性最重要的免疫性不孕因素。检测血清不孕五项相关自身抗体有助于临床免疫性不孕症的诊断。【关键词】自身抗体;不孕;女性TheSignificanceofDetectingRelatedAutoantibodiesInInfertileWomenHuangZeqi,ZbouShaoxiong,XieWeixian,JiangZhilan,DengAihong,ShenYongjian(TheSecondPeople’SHospitalofFoshan,GuangdongFoshan528000,China)【Abstract]Objec
4、tiveToinvestigatethesignificanceof5kindsoffemaleinfertility—relatedautoantibodiesfromtheserumofpatientswithinfertility.MethodsAnti—spermantibodies,anti—HCGantibody,anti—ovarianantibodies,anticardiolipinantibodiesandanti—endometrialantibodieswereanalyzedbyELISAinsetllmfrom16
5、8femaleinfertilityease.and66healthypersonshadgivenbirthasacontrolgroup.Re-suitsThepositivee.ase:sofanti—spermantibody,anti—HCGantibody,anti—ovarianantibody,anti—eardiolipinantibodyandanti—endome—trialantihedyinserumwere29,3,6,2and5in168easesoffemaleinfertility.Thepositivera
6、teswere17.3%,1.8%,3.6%,1.2%and3.O%.Thepositivecasesofanti—spermantibody,anti—HCGantibody,anti—ovarianantibody,anti—eardiolipinantibodyandanti—endome—trialantibodyinsel3Jmwere2,0,0,0and1in66casesofnormalcontrolgroup.Thepositiverateswere3.O%,0,0,0and1.5%.Thepositiverateofanti
7、—spermantibodyininfertilegroupwassignificantlyhigherthanthecontrolgroup(P<0.05).Thepositiveratesofanti—HCGanti—body,anti—ovarianantibody,anti—eardiolipinantibodyandanti—endometrialantibodyininfertilegroupwerehigherthanthecontrolgroup,butthediferencewerenotstatisticallysigni
8、ficant(P>0.05).ConclusionsTheanti—spermantibodiesisoneofthemostimportantimmunefema
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